Document Detail

Oxidative stress and antioxidant status in intensely exercising horses administered nutraceutical extracts.
MedLine Citation:
PMID:  21059024     Owner:  NLM     Status:  MEDLINE    
REASONS FOR PERFORMING STUDY: Many nutraceuticals are used as equine supplements without their efficacy having been scientifically tested. Black tea, cranberries, orange peel and ginger are a few of those nutraceuticals that warrant further study.
OBJECTIVE: To test the effects of single doses of black tea, cranberry, orange peel and ginger extract on markers of oxidative stress and antioxidant status following exercise in horses.
METHODS: In Study 1, 9 mature, healthy but unfit Standardbred mares were administered 2 l of a control (water), orange peel extract (30 g extract) or decaffeinated black tea extract (28 g extract). In Study 2 the same mares were administered 2 l of a control (water), cranberry extract (30 g extract) or ginger extract (30 g extract). In each study, mares were given the extracts via nasogastric tube 1 h before performing a graded exercise test (GXT), in a randomised crossover design with at least 7 days between GXTs. Blood samples were collected at rest, at fatigue, and 1 and 24 h post exercise and analysed for lipid hydroperoxides (LPO), total glutathione (GSH-T), glutathione peroxidase (GPx), α-tocopherol (TOC), β-carotene (BC) and retinol. Data were statistically analysed using a repeated measures ANOVA.
RESULTS: In Study 1 there was no effect of treatment for LPO, GSH-T, GPx, TOC or BC. Retinol was higher for both tea (P = 0.0006) and water (P = 0.004) than for orange peel. In Study 2 there was no treatment effect for LPO, GPx, GSH-T, RET, BC or TOC.
CONCLUSIONS: The results show that a single dose of various nutraceuticals in exercising horses do not produce an effect on either oxidative stress or antioxidant status and further investigation is needed as to whether long-term supplementation would enhance these effects.
D N Smarsh; N Liburt; J Streltsova; K McKeever; C A Williams
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-08-17     Revised Date:  2012-06-13    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Copyright Information:
© 2010 EVJ Ltd.
Department of Animal Science, Equine Science Center, Rutgers, the State University, New Jersey, USA.
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MeSH Terms
Antioxidants / metabolism
Cross-Over Studies
Dietary Supplements / analysis
Horses / blood,  physiology*
Oxidative Stress / drug effects*
Physical Conditioning, Animal / physiology*
Plant Extracts / chemistry,  pharmacology*
Water / chemistry*
Reg. No./Substance:
0/Antioxidants; 0/Plant Extracts; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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