Document Detail

Oxidative stress and antioxidant enzyme activities in newborns with oesophageal atresia and their mothers.
MedLine Citation:
PMID:  22429364     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To measure the oxidant/antioxidant status of newborn babies with oesophageal atresia and their mothers, compared with healthy control subjects.
METHODS: This case-control study included 40 participants: 10 newborns with oesophageal atresia and their mothers, and 10 healthy newborns and their mothers. Whole blood malondialdehyde (MDA) levels and the activities of antioxidant enzymes (catalase, carbonic anhydrase [CA], glucose-6-phosphate dehydrogenase [G-6-PD], and superoxide dismutase [SOD]) were measured.
RESULTS: MDA levels and CA activity were significantly higher, and catalase, SOD and G-6-PD activities were significantly lower, in newborns with oesophageal atresia and their mothers than in healthy newborns and their mothers. Although CA activity was similar between the newborns and mothers in the patient group, it was significantly lower in newborns than in mothers in the healthy group.
CONCLUSIONS: Increased lipid peroxidation might play an important role in the pathogenesis of oesophageal atresia. Impairment of the free radical/antioxidant balance may lead to increased free radical and decreased antioxidant levels in oesophageal atresia.
M Melek; H Demir; S Bilici; B Beger; U Cobanoğlu; I Meral; S Keskin; E Ozmen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  40     ISSN:  1473-2300     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Department of Paediatric Surgery, Medical Faculty, University of Yuzuncu Yil, Van, Turkey, Yuzuncu Yil Universitesi, Tip Fakultesi, Cocuk Cerrahisi Anabilim Dali, 65200 Merkez, Van, Turkey.
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