Document Detail

Oxidative stress and antioxidant activity of female rat liver tissue after sevoflurane anaesthesia: young versus old.
MedLine Citation:
PMID:  23173627     Owner:  NLM     Status:  In-Data-Review    
Aim: The aim of our study was to assess the evidence of oxidative stress in the rat liver tissue by studying enzymes, such as nitric oxide synthase (NOS), superoxide dismutase (SOD), glutathione-S transferase (GST) activity, and thiobarbutiric acid-reactive substances (TBARS) levels in young versus old female rats after sevoflurane anaesthesia. Material and method: The study involved 28 female Wistar Albino rats. The rats were divided into the two groups [(Group I, n=14): Young sevoflurane group (Group I-YS, n=7); Young control group (Group I-YC, n=7)], [(Group II, n=14): Old sevoflurane group (Group II-OS, n=7); Old control group (Group II-OC, n=7)]. Sevoflurane was administered at 2 % volume inspiratory concentration, 6 L.min-1 in 100 % O2 for 2 hours. The control groups were not subjected to any procedures. Accordingly, GST, SOD, and NOS enzyme activity and TBARS level, were studied in the liver tissue samples of the rats to determine the presence of oxidative stress (OS) and antioxidant activity.Results: Following administration of sevoflurane anaesthesia; GST, SOD enzyme activity and TBARS level was significantly higher in the Group I-YS than in the Group I-YC and in the Group II-OS than in the Group II-OC. There was no difference between the groups when the mean NOS levels were compared.Conclusion: Although the results of our study are similar to the previous indicating that sevoflurane has the capacity to induce the oxidative stress; a new data has been recorded that sevoflurane has a similar effect on the OS level in aged and young female rat (Tab. 1, Fig. 4, Ref. 48). Keywords: oxidative stress, liver tissue, rat, sevoflurane, GST, SOD, NOS, TBARS.
M Arslan; B Isik; M Kavutcu; O Kurtipek
Related Documents :
22763967 - Docosahexaenoic acid provides protective mechanism in bilaterally mptp-lesioned rat mod...
2464017 - Modification of guinea pig lung anaphylaxis by central nervous system (cns) perturbations.
20360627 - Systemic perfluorohexane attenuates lung injury induced by lipopolysaccharide in rats: ...
12873547 - Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.
18618337 - Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morph...
12507117 - Leksell gamma knife lesioning of the rat hippocampus: the relationship between radiatio...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  113     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  702-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected t...
Next Document:  The evaluation of Candida albicans biofilms formation on silicone catheter, PVC and glass coated wit...