| Oxidative stress, alpha-tocopherol therapy, and atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 12162937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Atherosclerosis is the leading cause of morbidity and mortality in the United States. Evidence suggests that antioxidants, especially alpha-tocopherol (AT), have potential benefits with respect to cardiovascular disease. AT has been shown to decrease lipid peroxidation, to inhibit platelet adhesion, aggregation, and smooth muscle cell proliferation, to exert anti-inflammatory effects on monocytes, and to improve endothelial function. Low levels of AT are related to a higher incidence of cardiovascular disease and increased intakes appear to afford protection against cardiovascular disease. Although clinical trials with AT supplementation to date have been conflicting, the majority of evidence supports a benefit for AT supplementation in patients with pre-existing cardiovascular disease. Clearly, more clinical trials are required in individuals with increased oxidative stress before a definitive recommendation can be made with respect to AT supplementation in atherosclerosis. |
| | |
Authors:
|
Andrea Harris; Sridevi Devaraj; Ishwarlal Jialal |
Related Documents
:
|
19747137 - Cardiovascular effects of losartan and its relevant clinical application. 18070367 - Peripheral arterial disease study (perart): prevalence and predictive values of asympto... 7605367 - Microalbuminuria is not associated with cardiovascular disease in patients with homozyg... 21621007 - Autoimmune diseases of the peripheral nervous system. 5259767 - Uroporphyrinogen 3 cosynthetase in human congenital erythropoietic porphyria. 14653357 - Basic and clinical aspects of copper. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current atherosclerosis reports Volume: 4 ISSN: 1523-3804 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-08-06 Completed Date: 2003-05-15 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 373-80 Citation Subset: IM |
Affiliation:
|
University of Texas Southwestern Medical Center, Dallas, 75390-09073, USA. jilal.i@pathology.swmed.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arteriosclerosis
/
drug therapy*,
mortality,
prevention & control* Dietary Supplements* Female Humans Hyperlipidemias / drug therapy, prevention & control* Lipid Peroxidation Male Oxidation-Reduction Oxidative Stress / drug effects Prognosis Randomized Controlled Trials as Topic Risk Assessment Risk Factors Sensitivity and Specificity Survival Rate Treatment Outcome alpha-Tocopherol / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
59-02-9/alpha-Tocopherol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in atherosclerosis.
Next Document: Noninvasive Studies of Coronary and Peripheral Arterial Blood-flow.