Document Detail


Oxidative stress and DNA damage in older adults that do exercises regularly.
MedLine Citation:
PMID:  19679117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Free radicals may damage lipids, proteins and DNA, which may lead to critical diseases in the aging. This work evaluated levels of malondialdehyde (MDA), glutathione peroxidase (GPx) and DNA damage by comet assay (SCGE) in older adults that do exercises regularly. DESIGN AND METHODS: 110 females, aged 66.3+/-8 years were divided into sedentary (n=54), walking (n=36) and muscle building (n=20) groups. Levels of MDA, GPx and SCGE were measured in venous blood before and after exercise. RESULTS: MDA levels were higher (P<0.005) and GPx levels were lower (P<0.005) in active groups than in sedentary group. SCGE index after physical activity was greater than at baseline (muscle building: P=0.004; walking: P=0.002). CONCLUSIONS: Exercise reduces the diseases risk, but may promote the production of free radicals. It remains unclear whether cell adaptations responsible for health benefits are associated with such events. However we may suggest the existence of a different biochemical pattern for older adults that do exercise regularly.
Authors:
Michelle Mergener; Maclóvia Rosso Martins; Marina Venzon Antunes; Caroline Calice da Silva; Camilla Lazzaretti; Tiago Oselane Fontanive; Edna Sayuri Suyenaga; Patrícia Grolli Ardenghi; Sharbel Weidner Maluf; Giovana Duzzo Gamaro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-11
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1648-53     Citation Subset:  IM    
Affiliation:
Biological and Health Center, UNIVATES, Lajeado-RS, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aged
Comet Assay
DNA Damage*
Exercise*
Female
Glutathione Peroxidase / metabolism
Humans
Malondialdehyde / metabolism
Middle Aged
Oxidative Stress*
Chemical
Reg. No./Substance:
542-78-9/Malondialdehyde; EC 1.11.1.9/Glutathione Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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