Document Detail

Oxidative stability of low density lipoproteins and vitamin E levels increase in maternal blood during normal pregnancy.
MedLine Citation:
PMID:  11383686     Owner:  NLM     Status:  MEDLINE    
In 24 healthy pregnant women, parameters related to the oxidative stability of low density lipoproteins (LDL) were determined at three times during pregnancy and shortly after delivery. The fatty acid composition of plasma phospholipids (PL) and the plasma concentrations of vitamin E, vitamin A, and beta-carotene were assessed in the same samples. Total triglyceride (TG), total cholesterol, LDL-cholesterol, and high density lipoprotein (HDL)-cholesterol concentrations were also determined. The length of the lag phase of isolated LDL challenged with Cu2+ ions significantly increased with the progression of pregnancy. The oxidation rate and the amount of conjugated dienes formed increased and reached a maximum at 29-37 wk of pregnancy. Total TG, cholesterol, and LDL-cholesterol reached a maximum in the third trimester of pregnancy. beta-Carotene remained stable, vitamin A decreased, and vitamin E significantly increased throughout pregnancy. Vitamin E plasma concentration correlated positively with the length of the lag phase. The increased levels of vitamin E could contribute to the higher resistance of LDL toward oxidation with progressing gestation, measured by the prolonged lag phase. Furthermore, vitamin E plasma levels correlated positively with TG concentration but not with LDL-cholesterol. The level of polyunsaturated fatty acids in PL decreased with the progression of pregnancy. No correlation was found between the fatty acid composition of plasma PL, nor with the cholesterol concentration, and the parameters studied related to the oxidative stability of LDL. The major finding of this study is the increased oxidative resistance of LDL with progressing gestation.
S R De Vriese; M Dhont; A B Christophe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  36     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-31     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-6     Citation Subset:  IM    
Department of Internal Medicine, Ghent University Hospital, Belgium.
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MeSH Terms
Antioxidants / metabolism
Cholesterol / blood
Drug Stability
Fatty Acids / blood*
Lipoproteins, LDL / blood*
Phospholipids / blood*
Pregnancy / blood*
Pregnancy Trimester, Third
Triglycerides / blood
Vitamin E / blood*
Vitamins / blood
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids; 0/Lipoproteins, LDL; 0/Phospholipids; 0/Triglycerides; 0/Vitamins; 0/oxidized low density lipoprotein; 1406-18-4/Vitamin E; 57-88-5/Cholesterol

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