Document Detail


Oxidative radicals and liver involvement of infants with alpha-1-antitrypsin deficiency.
MedLine Citation:
PMID:  1663223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low levels of alpha-1-antitrypsin can predispose deficient infants to the development of hepatitis and cirrhosis. Heterozygous PiMZ carriers can be affected by a subclinical liver involvement during their first half year of life. One pathogenic hypothesis of liver damage is that the process seems to be mediated by the activity of toxic oxygen waste products. In the present investigation it was found that the antioxidant vitamin E was able to significantly reduce the frequency of liver involvement in PiMZ carriers at two months of age but not at five months. These findings indicate that oxidative free radicals can promote liver damage in inadequately protected young infants, such as in alpha-1-antitrypsin deficiency. The protective role of vitamin E in relation to the developmental expression of other anti-oxidant scavengers is discussed.
Authors:
K Pittschieler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pädiatrie und Pädologie     Volume:  26     ISSN:  0030-9338     ISO Abbreviation:  Padiatr Padol     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0022370     Medline TA:  Padiatr Padol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  235-7     Citation Subset:  IM    
Affiliation:
Pädiatrische Gastroenterologie, Regionales Krankenhaus, Bozen, Italy.
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MeSH Terms
Descriptor/Qualifier:
Free Radicals
Hepatitis / drug therapy,  genetics*
Heterozygote
Homozygote
Humans
Hydrogen Peroxide / metabolism*
Infant
Liver Function Tests
Phenotype*
Superoxides / metabolism*
Vitamin E / administration & dosage
alpha 1-Antitrypsin / genetics
alpha 1-Antitrypsin Deficiency*
Chemical
Reg. No./Substance:
0/Free Radicals; 0/alpha 1-Antitrypsin; 11062-77-4/Superoxides; 1406-18-4/Vitamin E; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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