| Oxidative radicals and liver involvement of infants with alpha-1-antitrypsin deficiency. | |
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MedLine Citation:
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PMID: 1663223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low levels of alpha-1-antitrypsin can predispose deficient infants to the development of hepatitis and cirrhosis. Heterozygous PiMZ carriers can be affected by a subclinical liver involvement during their first half year of life. One pathogenic hypothesis of liver damage is that the process seems to be mediated by the activity of toxic oxygen waste products. In the present investigation it was found that the antioxidant vitamin E was able to significantly reduce the frequency of liver involvement in PiMZ carriers at two months of age but not at five months. These findings indicate that oxidative free radicals can promote liver damage in inadequately protected young infants, such as in alpha-1-antitrypsin deficiency. The protective role of vitamin E in relation to the developmental expression of other anti-oxidant scavengers is discussed. |
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Authors:
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K Pittschieler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pädiatrie und Pädologie Volume: 26 ISSN: 0030-9338 ISO Abbreviation: Padiatr Padol Publication Date: 1991 |
Date Detail:
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Created Date: 1992-02-27 Completed Date: 1992-02-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0022370 Medline TA: Padiatr Padol Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 235-7 Citation Subset: IM |
Affiliation:
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Pädiatrische Gastroenterologie, Regionales Krankenhaus, Bozen, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Free Radicals Hepatitis / drug therapy, genetics* Heterozygote Homozygote Humans Hydrogen Peroxide / metabolism* Infant Liver Function Tests Phenotype* Superoxides / metabolism* Vitamin E / administration & dosage alpha 1-Antitrypsin / genetics alpha 1-Antitrypsin Deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/alpha 1-Antitrypsin; 11062-77-4/Superoxides; 1406-18-4/Vitamin E; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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