Document Detail

Oxidative phosphorylation in mitochondria isolated from stressed rat heart.
MedLine Citation:
PMID:  1215639     Owner:  NLM     Status:  MEDLINE    
Oxidative phosphorylation was measured polarographically in mitochondria isolated from rat heart. With regard to ADP/O ratio and respiratory control index, no differences were found among mitochondria isolated from normal, acutely (increased pneumatic resistance of the heart-lung preparation) and chronicly (renal hypertension) stressed heart. However, the acute stressed heart induced by strangulating the outflow tract of the heart-lung preparation showed clear depression and tendency to depression, respectively, in the level of ADP/O ratio and respiratory control index in mitochondria. The results indicate that there is no change in the oxidative phosphorylating mechanism of the myocardial mitochondria of nonfailed heart despite acute or chronic pressure loadings; however, there is an uncoupling of oxidative phosphorylation in mitochondria of the failed heart after acute strangulation of the outflow tract.
M Nagano; S Mochizuki; T Kogure; T Kosuga; N Saito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  8     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:  1975  
Date Detail:
Created Date:  1976-04-10     Completed Date:  1976-04-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  IM    
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MeSH Terms
Adenosine Diphosphate / metabolism
Mitochondria, Muscle / metabolism*
Myocardium / metabolism*,  ultrastructure
Oxidative Phosphorylation*
Oxygen Consumption
Stress, Physiological / metabolism*
Reg. No./Substance:
58-64-0/Adenosine Diphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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