Document Detail


Oxidative phosphorylation and aspects of calcium metabolism in myocardia of hypercholesterolaemic swine with moderate coronary atherosclerosis.
MedLine Citation:
PMID:  203397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aspects of myocardial oxidative phosphorylation and Ca2+ metabolism were studied in a swine model in which coronary atherosclerosis was induced by a combination of denudation of the endothelium of the coronary arteries plus 7--11 months of feeding a high fat--high cholesterol diet. By microscopy, a moderate amount of coronary atherosclerosis was present at the time of sacrifice, and 2 of the 14 swine hearts had old myocardial infarcts. Myocardial mitochondria from grossly normal areas showed partial uncoupling and decreased state 3 O2 uptake with 3 of 4 substrates tested. In addition, Ca2+ stimulated mitochondrial respiration was decreased in the atherosclerotic swine. In the sarcoplasmic reticulum Ca2+ uptake under conditions of heavy loading was greater in the atherosclerotic swine than in control animals. The degree of atherosclerosis was not great enough to suggest that persistent myocardial ischaemia was present. Possibly coronary artery spasm induced an intermittent ischaemia resulting in the metabolic abnormalities observed, or the changes may have been brought about by the effects of the high fat--high cholesterol diet on subcellular membranes.
Authors:
E S Morrison; R F Scott; W M Lee; J Frick; M Kroms; C P Cheney
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  11     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriosclerosis / etiology,  metabolism*
Calcium / metabolism*
Coronary Disease / metabolism*
Electron Transport Complex IV / metabolism
Hypercholesterolemia / complications
Male
Mitochondria, Heart / metabolism
Myocardium / metabolism*,  ultrastructure
Oxidative Phosphorylation*
Oxygen Consumption
Sarcoplasmic Reticulum / metabolism
Swine
Chemical
Reg. No./Substance:
7440-70-2/Calcium; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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