Document Detail

Oxidative phosphorylation and aspects of calcium metabolism in myocardia of hypercholesterolaemic swine with moderate coronary atherosclerosis.
MedLine Citation:
PMID:  203397     Owner:  NLM     Status:  MEDLINE    
Aspects of myocardial oxidative phosphorylation and Ca2+ metabolism were studied in a swine model in which coronary atherosclerosis was induced by a combination of denudation of the endothelium of the coronary arteries plus 7--11 months of feeding a high fat--high cholesterol diet. By microscopy, a moderate amount of coronary atherosclerosis was present at the time of sacrifice, and 2 of the 14 swine hearts had old myocardial infarcts. Myocardial mitochondria from grossly normal areas showed partial uncoupling and decreased state 3 O2 uptake with 3 of 4 substrates tested. In addition, Ca2+ stimulated mitochondrial respiration was decreased in the atherosclerotic swine. In the sarcoplasmic reticulum Ca2+ uptake under conditions of heavy loading was greater in the atherosclerotic swine than in control animals. The degree of atherosclerosis was not great enough to suggest that persistent myocardial ischaemia was present. Possibly coronary artery spasm induced an intermittent ischaemia resulting in the metabolic abnormalities observed, or the changes may have been brought about by the effects of the high fat--high cholesterol diet on subcellular membranes.
E S Morrison; R F Scott; W M Lee; J Frick; M Kroms; C P Cheney
Related Documents :
14650357 - Secondary prevention of coronary artery disease in high-risk diabetic patients.
11985777 - The myocardial ischemia reduction with acute cholesterol lowering trial: miraculous or ...
2685177 - Program on the surgical control of the hyperlipidemias (posch): design and methodology....
9192327 - Paradise regained: insights into coronary heart disease prevention from recent clinical...
2427857 - Comparison of the acute hemodynamic effects of intravenous celiprolol and propranolol i...
15156007 - Treatment of saphenous vein graft thrombosis with distal protection, thrombectomy, and ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  11     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arteriosclerosis / etiology,  metabolism*
Calcium / metabolism*
Coronary Disease / metabolism*
Electron Transport Complex IV / metabolism
Hypercholesterolemia / complications
Mitochondria, Heart / metabolism
Myocardium / metabolism*,  ultrastructure
Oxidative Phosphorylation*
Oxygen Consumption
Sarcoplasmic Reticulum / metabolism
Reg. No./Substance:
7440-70-2/Calcium; EC Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cyclic adenosine 3':5'-monophosphate and methotrexate transport in L1210 cells.
Next Document:  The eyes of mesopelagic crustaceans. II. Streetsia challengeri (amphipoda).