| Oxidative phenotype polymorphism (P450 2D6) and metabolism of toluene. | |
| | |
MedLine Citation:
|
PMID: 8688995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxidative phenotype P-450 2D6 was examined using sparteine test in 3 groups of persons to determine if there is a coincidence in the defect of the oxidative biotransformation of sparteine and impaired oxidation of toluene, which could explain interindividual differences in the amounts of hippuric acid in the urine in exposed persons. The following groups of persons were examined: 30 rotogravure printers exposed to toluene vapors at concentrations of 8-307 ppm; 20 workers, 2 months after the cessation of the long-term exposure to toluene at concentrations of 104-1,170 ppm; 48 healthy volunteers with no exposure to toluene. Among the 98 persons 5 poor metabolizers (PMs) of sparteine were found, none in the group of printers exposed to toluene. In the experimental exposure chamber 5 PMs and 6 extensive metabolizers (EMs) were exposed to toluene concentration of 245 ppm for 5 hours. Hippuric acid and o-cresol in the urine, and toluene both in blood and in alveolar air were measured. However, no significant differences were found in either of these parameters between the PM and EM groups. Thus, the sparteine test does not appear to be applicable in the identification of persons with higher risk arising from toluene exposure. |
| | |
Authors:
|
D Pelclová; J Mráz; V Patzelová; J Pícková; J Pospísil; L Vodicková; M Hornychová; J Vejlupková |
Related Documents
:
|
969565 - Studies on the metabolism of d-limonene (p-mentha-1,8-diene). iv. isolation and charact... 9884325 - In vivo studies on chiral inversion and amino acid conjugation of 2-[4-(3-methyl-2-thie... 6722055 - Thin layer chromatography of p-aminophenol in urine after mixed exposure to aniline and... 14723955 - Metabolism of 5'alpha,8'-cycloabscisic acid, a highly potent and long-lasting abscisic ... 4625625 - Mode of action of primaquine: preferential inhibition of protein biosynthesis in bacill... 16608885 - Altered cardiac fatty acid composition and utilization following dexamethasone-induced ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of clinical pharmacology and therapeutics Volume: 34 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 1996 Jan |
Date Detail:
|
Created Date: 1996-08-27 Completed Date: 1996-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 38-42 Citation Subset: IM |
Affiliation:
|
Department of Occupational Diseases, Charles University, Prague, Czech Republic. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Biotransformation Cresols / urine Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System / metabolism* Hippurates / urine Humans Mixed Function Oxygenases / metabolism* Occupational Exposure Oxidation-Reduction Oxytocics / metabolism, urine Phenotype Polymorphism, Genetic Rats Sparteine / metabolism, urine Toluene / metabolism*, urine Xenobiotics / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cresols; 0/Hippurates; 0/Oxytocics; 0/Xenobiotics; 108-88-3/Toluene; 495-69-2/hippuric acid; 90-39-1/Sparteine; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Cytochrome P-450 CYP2D6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bioequivalence study of alpha-dihydroergocryptine: utility of metabolite evaluation.
Next Document: Utilization of antidiabetic drugs in Hong Kong: relation to the common occurrence of antidiabetic dr...