Document Detail

Oxidative metabolism and phagocytosis of polymorphonuclear leukocytes in patients with chronic renal failure.
MedLine Citation:
PMID:  3412545     Owner:  NLM     Status:  MEDLINE    
The respiratory burst activity (generation of hydrogen peroxide) of peripheral polymorphonuclear leukocytes (PMN) in both phorbol myristate acetate (PMA)-stimulated and unstimulated states and phagocytosis were assessed using flow cytometry on 46 patients with chronic renal failure: 33 patients undergoing chronic hemodialysis (CHD), 8 patients who have never been on dialysis (nonhemodialysis; NHD), 5 patients undergoing continuous ambulatory peritoneal dialysis (CAPD); these patients were compared with 27 normal control subjects. In patients just before the initiation of dialysis, impaired hydrogen peroxide production by PMA-stimulated PMN and depressed phagocytosis were noted, which was restored to the control levels by hemodialysis. A mild but significant reduction of hydrogen peroxide production in a PMA-stimulated state was found in NHD patients, and an inverse correlation was noted between the impairment of this function and the degree of diminished renal function. There was no significant difference between CAPD patients and controls in hydrogen peroxide production by PMA-stimulated PMN. Decreased hydrogen peroxide production by unstimulated PMN was observed in both CHD and CAPD patients. These findings may explain, at least partly, the enhanced susceptibility to bacterial and fungal infections of these patients.
Y Hirabayashi; T Kobayashi; A Nishikawa; H Okazaki; T Aoki; J Takaya; Y Kobayashi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  49     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-11     Completed Date:  1988-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  305-12     Citation Subset:  IM    
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
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MeSH Terms
Flow Cytometry
Hydrogen Peroxide / metabolism
Kidney Failure, Chronic / immunology*,  therapy
Lymphocyte Activation
Neutrophils / physiology*
Oxygen Consumption
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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