| Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 8740985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucose metabolism in the brain has an important influence on many normal cellular processes. It contributes to the synthesis of acetylcholine, glutamate, aspartate, gamma-aminobutyric acid, glycine, and ATP production (the driving force behind almost all cellular and molecular activity). Neuronal glucose metabolism is controlled antagonistically by insulin and cortisol. Desensitization of the neuronal insulin receptor causes abnormalities in oxidative energy metabolism. During normal aging, the cerebral energy pool is slightly diminished, but its level increases after stressful events. In age-related sporadic late-onset dementia of the Alzheimer type (SDAT), glucose metabolism and formation of cellular energy are severely reduced. Desensitization of the neuronal insulin receptor seems to be an early event in the pathogenesis or even etiology of SDAT causing disturbances in oxidative glucose metabolism and energy failure in insulin-sensitive brain structures. These abnormalities appear to induce a cascade of disturbances that leads to abnormal APP processing and amyloid formation, membrane damage, and neuronal death. |
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Authors:
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S Hoyer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta neurologica Scandinavica. Supplementum Volume: 165 ISSN: 0065-1427 ISO Abbreviation: Acta Neurol. Scand., Suppl.c Publication Date: 1996 |
Date Detail:
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Created Date: 1996-11-27 Completed Date: 1996-11-27 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0370337 Medline TA: Acta Neurol Scand Suppl Country: DENMARK |
Other Details:
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Languages: eng Pagination: 18-24 Citation Subset: IM |
Affiliation:
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Institut for Patochemie und Allgemeine Neurochemie, Ruprecht-Karis Universitat, Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism* Brain / metabolism* Glucose / metabolism* Humans |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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