Document Detail


Oxidative metabolism of N-phenyllinoleamide by human nasal polyps.
MedLine Citation:
PMID:  1475378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-phenyllinoleamide (NPLA), the anilide of linoleic acid, has been associated with the epidemiology of Toxic Oil Syndrome, but no data are available on its metabolism. On account of the similarity in chemical structure between the linoleic acid and NPLA, the aim of this study has been to investigate the oxidative metabolism of this xenobiotic by the human nasal polyp, a tissue with elevated 15-lipoxygenase activity. For this purpose, tissue homogenates have been incubated for 2 h with NPLA (0.1 mM) spiked with either N-(ring G-3H)PLA (0.2 microCi/ml) or N-P(1-14C)LA (0.05 microCi/ml). Gas chromatographic/mass spectrometric analysis of the high performance liquid radiochromatographic fractions shows that the 9,12,13-trihydroxy, 12,13-epoxy-11-hydroxy and 13-hydroxy NPLA derivatives are the major metabolites. These results revealed that NPLA metabolites are chemical structures related to the linoleic acid derivatives, some of which may show biological activity.
Authors:
G Bioque; I Ramis; A I Mallet; O Bulbena; J Rosello-Catafau; E Gelpi
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  44     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-04     Completed Date:  1993-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  597-609     Citation Subset:  IM    
Affiliation:
Department of Neurochemistry, Centro de Investigacion y Desarrollo, CSIC, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Anilides / metabolism*
Chromatography, High Pressure Liquid
Gas Chromatography-Mass Spectrometry
Humans
Linoleic Acids / metabolism*
Molecular Structure
Nasal Polyps / metabolism*
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Anilides; 0/Linoleic Acids; 19878-10-5/linoleylanilide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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