Document Detail

Oxidative injury to erythrocytes, cell rigidity and splenic hemolysis in hemodialyzed patients before and during erythropoietin treatment.
MedLine Citation:
PMID:  8247195     Owner:  NLM     Status:  MEDLINE    
The oxidative injury to erythrocytes, red blood cell (RBC) rigidity and splenic hemolysis was assayed in 17 chronically hemodialyzed patients before and during recombinant erythropoietin (EPO) treatment. When a stable hematocrit between 30 and 35% had been established for at least 4 months, a statistically significant increase in RBC volume, hemoglobin concentration, hematocrit, reticulocyte count, and several RBC enzymes (2,3-diphosphoglycerate, glucose 6-phosphate dehydrogenase, pyruvate kinase, hexokinase) was noted. This indicated significant RBC rejuvenation under the influence of EPO. However, no significant improvement in the RBC oxidative sensitivity, RBC deformability, splenic RBC volume, slow mixing splenic RBC volume, and the intrasplenic RBC transit time could be disclosed. These data confirm the existence of an extra-erythrocytic factor in uremic plasma, which is partly responsible for a reduced RBC life span in hemodialysis patients despite EPO treatment.
P Zachée; A Ferrant; R Daelemans; L Coolen; W Goossens; R L Lins; M Couttenye; M E De Broe; M A Boogaerts
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  65     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-05     Completed Date:  1994-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  288-93     Citation Subset:  IM    
Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Anemia / blood,  etiology
Erythrocyte Aging / drug effects
Erythrocyte Deformability / drug effects*,  physiology
Erythrocytes / cytology,  drug effects,  metabolism*
Erythropoiesis / drug effects
Erythropoietin / adverse effects,  therapeutic use*
Kidney Failure, Chronic / blood*,  complications,  therapy
Middle Aged
Reactive Oxygen Species / metabolism
Renal Dialysis / adverse effects*
Sensitivity and Specificity
Spleen / cytology,  drug effects
Uremia / blood
Reg. No./Substance:
0/Reactive Oxygen Species; 11096-26-7/Erythropoietin

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