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Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia.
MedLine Citation:
PMID:  24321755     Owner:  NLM     Status:  Publisher    
This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral markers. Serum levels of hydroperoxides, homocysteine, advanced oxidation protein products, uric acid, thiols, and total and residual antioxidant power were assessed in 103 mild cognitive impairment (MCI), 89 LOAD, 54 VAD patients and 48 Controls. Compared with Controls, a similar oxidative unbalance (high hydroperoxides and low residual antioxidant power) was observed in MCI, LOAD and, although less pronounced, VAD. Moreover, individuals with simultaneously high levels of homocysteine and uric acid, both well-known risk factors for cardiovascular disease, had a high probability to be affected by VAD (O.R.:10.50; 95% C.I.: 2.33-47.2), but not LOAD (O.R.: 3.0; 95% C.I.:0.86-10.76) compared with individuals with normal values. Our data suggest that, although they might share a common OxS-related pathogenesis, VAD and LOAD might maintain some distinctive features, with a predominance of "vascular component" in VAD compared with LOAD.
Carlo Cervellati; Arianna Romani; Davide Seripa; Eleonora Cremonini; Cristina Bosi; Stefania Magon; Angelina Passaro; Carlo M Bergamini; Alberto Pilotto; Giovanni Zuliani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-4
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, 44121 Ferrara, Italy. Electronic address:
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