Document Detail

Oxidative Stress in COPD Patients, Smokers and Non-Smokers Subjects.
MedLine Citation:
PMID:  22710284     Owner:  NLM     Status:  Publisher    
BACKGROUND: Oxidative stress has been known for having a key role in pathogenesis of many diseases. The aim of this study was to investigate the oxidative stress and also the relationship between antioxidant system statuses and lung function in patients with COPD and smokers and non-smokers subjects. METHODS: Thirty patients with COPD, 30 smokers and 30 healthy non-smokers participated in this study. The investigation included determination of the lung function and the measurements of plasma ceruloplasmin, ferritin, and total antioxidant capacity, also erythrocyte glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase. RESULTS: Plasma ceruloplasmin, ferritin and erythrocyte glutathione peroxidase andglutathione reductase were not significantly different between the studied groups. Patients with COPD and smokers had lower catalase and superoxide dismutase activity (p<0.01) than the non-smoker group. Levels of antioxidant capacity were significantly lower in patients with COPD and smokers than in non-smoker group (p<0.01). Regression analysis revealed no correlations between antioxidant status and spirometric data. CONCLUSIONS: Decreased total antioxidant capacity in plasma of patients with COPD and smokers suggests an increased oxidative stress in this group. However no relationship was found between lung function and antioxidant systems status in COPD patients.
Heidar Tavilani; Ebrahim Nadi; Jamshid Karimi; Mohammad Taghi Goodarzi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-15
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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