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Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome.
MedLine Citation:
PMID:  21126197     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Metabolic syndrome (MetS) is characterized by accumulation of visceral fat associated with the clustering of metabolic and pathophysiological cardiovascular risk factors: impaired glucose tolerance, dyslipidemia, and hypertension. Although the definition of MetS is different among countries, visceral obesity is an indispensable component of MetS. A growing body of evidence suggests that increased oxidative stress to adipocytes is central to the pathogenesis of cardiovascular disease in MetS. Increased oxidative stress to adipocytes causes dysregulated expression of inflammation-related adipocytokines in MetS, which contributes to obesity-associated vasculopathy and cardiovascular risk primarily through endothelial dysfunction. The purpose of present review is to unravel the mechanistic link between oxidative stress and cardiovascular risk in MetS, focusing on insulin resistance, hypertension, and atherosclerosis. Then, therapeutic opportunities translated from the bench to bedside will be provided to develop novel strategies to cardiovascular risk factors in MetS. Antioxid. Redox Signal. 15, 1911-1926.
Authors:
Hajime Otani
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Publication Detail:
Type:  Journal Article     Date:  2011-05-06
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  15     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1911-26     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Kansai Medical University , Moriguchi City, Japan .
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