Document Detail


Oxidative Stress and Persistent Pulmonary Hypertension of the Newborn treated with Inhaled Nitric Oxide and Different Oxygen Concentrations.
MedLine Citation:
PMID:  22320379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objectives: The aim of this study was to determine the effects of inhaled NO with different oxygen concentrations on the inflammatory cascade in newborns with hypoxic respiratory failure (HRF) secondary to persistent pulmonary hypertension. Methods: 60 newborns received iNO and 30 of them received an initial oxygen concentration of 45% (group 1), while the other 30 newborns received an initial oxygen concentration of 80% (group 2). The levels of inflammatory cytokines (IL-6, IL-8, TNF-α) were measured. The clinical outcome was also recorded. Results: The findings show that interleukin concentrations (IL-6, IL-8, TNF-α) were significantly decreased between 0 to 72 hours (p <0.01) in the newborns exposed to initial oxygen concentration of 45% and significantly increased in the other group. Conclusions: When inhaled NO was co-administered with concentration of O(2) < 45%, anti-inflammatory responses occurred, in accord with evidence in the published literature. The benefits of iNO on the clinical outcome in the current study demonstrate that inhaled NO in both groups was associated with improved short-term oxygenation.
Authors:
Gitto E; Pellegrino S; Aversa S; Romeo C; Trimarchi G; Barberi I; Calabró Mp; Salpietro Cd; Reiter Rj
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-9
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neonatal Intensive Care Unit, Department of Pediatrics, University of Messina, Italy.
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