Document Detail

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases.
MedLine Citation:
PMID:  22020018     Owner:  NLM     Status:  Publisher    
Exhaled breath condensate (EBC) is assumed to reflect processes in the lungs, yet it is unknown whether oxidative stress markers in EBC are affected by systemic disorders (atherosclerosis, hypertension, diabetes) or whether lung diseases increase markers in plasma and urine. 8-isoprostane, 4-hydroxy-trans-2-nonenale (HNE) and malondialdehyde (MDA) were measured using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) in EBC, plasma and urine in 82 patients (45 with asbestosis and hyalinosis, and 37 with silicosis) and in 29 control subjects. 8-isoprostane and HNE in EBC, and HNE in urine were higher in both groups of patients. In addition, 8-isoprostane in plasma and urine, and MDA in urine were higher in asbestos-exposed patients and MDA in plasma in silicotics, with this marker in plasma correlated with the grade of silicosis. In all subjects, 8-isoprostane in EBC correlated with urine (r=0.38, p<0.001) and plasma levels (r=0.28, p=0.003), and HNE and MDA with urine levels (r=0.31, p<0.001; r=0.23, p=0.016, respectively). Most markers positively correlated with lung function impairment, EBC markers negatively with vitamin E supplementation. To conclude: The influence of satisfactorily controlled systemic disorders on markers in EBC in patients with pneumoconioses is not significant. In addition to oxidative stress markers in EBC, lung fibroses may increase oxidative stress markers in plasma and urine.
Daniela Pelclová; Zdenka Fenclová; Kamila Syslová; Stěpánka Vlčková; Jindřiška Lebedová; Ondřej Pecha; Jaromír Běláček; Tomáš Navrátil; Marek Kuzma; Petr Kačer
Related Documents :
2229438 - Immunoblot technique to visualise serum pepsinogen a isozymogen patterns.
7151278 - Radioimmunoassay of serum group i and group ii pepsinogens in normal controls and patie...
6806138 - Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients wit...
594618 - Radioimmunoassay of serum gastrin in chronic digestive diseases with epigastric pain.
1033828 - Total and free testosterone and total and free 17 beta-oestradiol in normally menstruat...
3810048 - Carcinoembryonic antigen (cea) in blood in cases of pneumonia.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Industrial health     Volume:  -     ISSN:  1880-8026     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Charles University in Prague, 1st Faculty of Medicine, Department of Occupational Medicine of the 1st Faculty of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of Air Distribution on Efficiency of Dust Capture from Metal Grinding - Bench Test Method.
Next Document:  The Effect of Wok Size and Handle Angle on the Maximum Acceptable Weights of Wok Flipping by Male Co...