| Oxidative Stress Increases the Number of Stress Granules in Senescent Cells and Triggers a Rapid Decrease in p21waf1/cip1 Translation. | |
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MedLine Citation:
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PMID: 19176530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Very little is known as to how the accumulation of senescent cells during aging may affect our ability to cope with various stresses. Here we show that the assembly of stress granules (SGs) is part of the early events used by senescent cells to respond to certain stresses. Although SGs can form in response to stress during senescence activation, their number significantly increases once the cells are fully senescent. This increase correlates with a rapid decrease in the expression levels of the cyclin kinase inhibitor p21, an important activator of senescence. Throughout stress, p21 mRNA is stabilized and localizes to SGs, but only during late senescence does this localization interferes with its translation. Additionally, we observed that when the stress is relieved, senescent cells produce lower levels of p21 protein, which correlates with a small delay in SG disassembly. Therefore, our data suggest that SG formation and the reduction in p21 protein levels represent two main events by which senescent cells respond to stress. |
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Authors:
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Xian Jin Lian; Imed-Eddine Gallouzi |
Publication Detail:
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Type: Journal Article Date: 2009-01-28 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 284 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-05-26 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 8877-87 Citation Subset: IM |
Affiliation:
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Biochemistry Department, McGill University, Montreal H3G 1Y6, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Aging
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physiology* Cell Line Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis* Cytoplasmic Granules / metabolism* Humans Oxidative Stress / physiology* Protein Biosynthesis / physiology* RNA Stability / physiology RNA, Messenger / metabolism |
| Chemical | |
Reg. No./Substance:
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0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/RNA, Messenger |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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