Document Detail


Oxidative stress impairs endothelial function in nondipper hypertensive patients.
MedLine Citation:
PMID:  20553284     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aims: Essential hypertension, as well as other established cardiovascular risk factors, is associated with endothelial dysfunction. Hypertensive patients with a nondipper circadian pattern have a greater risk of cerebrovascular and cardiovascular complications in comparison with those with a dipper circadian pattern. In this study, we evaluated the association between nondipper pattern and endothelial function in patients with essential hypertension. Methods: We evaluated the forearm blood flow (FBF) response to intraarterial acetylcholine (ACh), an endothelium-dependent vasodilator, and sodium nitroprusside (SNP), an endothelium-independent vasodilator, infusions in 190 hypertensive patients stratified according to dipper and nondipper status. The FBF was measured by strain-gauge plethysmography. Effects of oxidative stress on FBF were evaluated by intraarterial infusion of vitamin C. Ambulatory BP monitorings were obtained by a validated oscillometric device (SpaceLabs 90207 Monitor Inc., Issaquah, WA, USA). Results: Systolic and diastolic blood pressures were higher during daytime and lower during night-time in dipper subjects than in nondippers. The peak percent increase in ACh-stimulated FBF was higher in dippers than in nondippers (473% vs. 228%, P < 0.001). The FBF responses to SNP were similar in dipper and nondipper patients. The FBF response to ACh during coinfusion of vitamin C was higher in nondippers rather than in dipper hypertensives. Conclusions: Present data demonstrate that endothelium-dependent vasodilation is impaired in patients who have nondipper hypertension. The effects of vitamin C on impaired ACh-stimulated vasodilation support the hypothesis that oxidative stress contributes to endothelial dysfunction of nondipper hypertensive patients.
Authors:
Raffaele Maio; Maria Perticone; Angela Sciacqua; Eliezer J Tassone; Paola Naccarato; Chiara Bagnato; Gianmarco Iannopollo; Giorgio Sesti; Francesco Perticone
Related Documents :
10359944 - Propionyl-l-carnitine dilates human subcutaneous arteries through an endothelium-depend...
11085964 - Impairment of endothelium-dependent vasodilation of resistance vessels in patients with...
14725334 - Effect of long-term irbesartan treatment on endothelium-dependent vasodilation in essen...
15982914 - The role of nitric oxide in regulation of the cardiovascular system in reptiles.
24006574 - Modification of an ultrasonic scaler for portable use.
18054844 - Diminished baroreflex-induced vasoconstriction following alpha-2 adrenergic receptor bl...
Publication Detail:
Type:  Journal Article     Date:  2010-06-11
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  30     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Department of Experimental and Clinical Medicine "G. Salvatore", University Magna Graecia of Catanzaro, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chronotropic incompentence and functional capacity in chronic heart failure: no role of ?-blockers a...
Next Document:  Regression of cardiac valvulopathy related to ergot-derived dopamine agonists.