Document Detail


Oxidative stress contributes to sex differences in blood pressure in adult growth-restricted offspring.
MedLine Citation:
PMID:  22585945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous experimental studies suggest that oxidative stress contributes to the pathophysiology of hypertension and, importantly, that oxidative stress plays a more definitive role in mediating hypertension in males than in females. Intrauterine growth restriction induced by reduced uterine perfusion initiated at day 14 of gestation in the rat programs hypertension in adult male growth-restricted offspring; yet, female growth-restricted offspring are normotensive. The mechanisms mediating sex differences in blood pressure in adult growth-restricted offspring are not clear. Thus, this study tested the hypothesis that sex-specific differences in renal oxidative stress contribute to the regulation of blood pressure in adult growth-restricted offspring. A significant increase in blood pressure measured by telemetry in male growth-restricted offspring (P<0.05) was associated with a marked increase in renal markers of oxidative stress (P<0.05). Chronic treatment with the antioxidant Tempol had no effect on blood pressure in male control offspring, but it normalized blood pressure (P<0.05) and renal markers of oxidative stress (P<0.05) in male growth-restricted offspring relative to male control offspring. Renal markers of oxidative stress were not elevated in female growth-restricted offspring; however, renal activity of the antioxidant catalase was significantly elevated relative to female control offspring (P<0.05). Chronic treatment with Tempol did not significantly alter oxidative stress or blood pressure measured by telemetry in female offspring. Thus, these data suggest that sex differences in renal oxidative stress and antioxidant activity are present in adult growth-restricted offspring and that oxidative stress may play a more important role in modulating blood pressure in male but not female growth-restricted offspring.
Authors:
Norma B Ojeda; Bettye Sue Hennington; Danielle T Williamson; Melanie L Hill; Nicole E E Betson; Julio C Sartori-Valinotti; Jane F Reckelhoff; Thomas P Royals; Barbara T Alexander
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-05-14
Journal Detail:
Title:  Hypertension     Volume:  60     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-09-07     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-22     Citation Subset:  IM    
Affiliation:
Departments of Pediatrics, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Antioxidants / pharmacology
Blood Pressure / drug effects,  physiology*
Blood Pressure Determination / methods
Catalase / metabolism
Cyclic N-Oxides / pharmacology
Female
Fetal Growth Retardation / physiopathology*
Glutathione Peroxidase / metabolism
Hypertension / physiopathology*
Kidney / drug effects,  metabolism
Male
Oxidative Stress / drug effects,  physiology*
Pregnancy
Rats
Rats, Sprague-Dawley
Sex Factors
Spin Labels
Superoxide Dismutase / metabolism
Superoxides / metabolism
Telemetry / methods
Grant Support
ID/Acronym/Agency:
HL074927/HL/NHLBI NIH HHS; HL51971/HL/NHLBI NIH HHS; P01 HL051971/HL/NHLBI NIH HHS; P20GM103476/GM/NIGMS NIH HHS; P20MD002725/MD/NIMHD NIH HHS; P20RR016476/RR/NCRR NIH HHS; R01 HL066072/HL/NHLBI NIH HHS; R01 HL074927/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cyclic N-Oxides; 0/Spin Labels; 11062-77-4/Superoxides; 2226-96-2/tempol; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase
Comments/Corrections
Comment In:
Hypertension. 2012 Aug;60(2):e14; author reply e15   [PMID:  22753209 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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