Document Detail

Oxidative stress and cardiovascular risk in overweight children in an exercise intervention program.
MedLine Citation:
PMID:  23270535     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study aimed to determine whether oxidative stress was related to cardiovascular risk indices in children, and whether an exercise intervention would reduce oxidative stress.
METHODS: A randomized trial of two different doses of exercise and a no-exercise control group included 112 overweight and obese children, 7-11 years old. Plasma isoprostane levels were obtained at baseline and after the intervention. Cross-sectional analysis of oxidative stress and metabolic markers at baseline was performed. The effect of the exercise training on oxidative stress was tested.
RESULTS: Lower isoprostane levels were observed in blacks. At baseline, isoprostane was positively related to measures of fatness (BMI, waist circumference, percent body fat), insulin resistance and β-cell function (fasting insulin, insulin area under the curve, Matsuda index, disposition index, oral disposition index), and several lipid markers (low-density lipoprotein, triglycerides, total cholesterol), and inversely with fitness [peak oxygen consumption (VO(2))], independent of race, sex, and cohort. No relation was found with visceral fat, blood pressure, or glycemia. Independent of percent body fat, isoprostane predicted triglycerides, β=0.23, total cholesterol-to-high-density lipoprotein (TC/HDL) ratio, β=0.23, and insulin resistance (insulin area under the curve, β=0.24, Matsuda index, β=-0.21, oral disposition index, β=0.33). Exercise did not reduce oxidative stress levels, despite reduced fatness and improved fitness in these children.
CONCLUSIONS: Isoprostane levels were related to several markers of cardiovascular risk at baseline; however, despite reduced fatness and improved fitness, no effect of exercise was observed on isoprostane levels. To our knowledge, this is the first report in children to demonstrate a correlation of oxidative stress with disposition index, fitness, and TC/HDL ratio, the first to test the effect on oxidative stress of an exercise intervention that reduced body fat, and the first such exercise intervention study to include a substantial proportion of black children.
B Adam Dennis; Adviye Ergul; Barbara A Gower; Jerry D Allison; Catherine L Davis
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-12-27
Journal Detail:
Title:  Childhood obesity (Print)     Volume:  9     ISSN:  2153-2176     ISO Abbreviation:  Child Obes     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-29     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101542497     Medline TA:  Child Obes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Blood Glucose / metabolism*
Body Mass Index
Cardiovascular Diseases / blood,  etiology,  prevention & control*
Cross-Sectional Studies
Exercise Therapy*
Insulin / blood
Insulin Resistance
Intervention Studies
Isoprostanes / blood*
Lipids / blood
Metabolic Syndrome X / blood,  epidemiology,  therapy*
Obesity / blood,  complications,  prevention & control*
Oxidative Stress*
Oxygen Consumption
Risk Factors
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 0/Isoprostanes; 0/Lipids

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