Document Detail


Oxidative stress and COPD: the effect of oral antioxidants on skeletal muscle fatigue.
MedLine Citation:
PMID:  23299763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Oxidative stress may contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). This study sought to determine the effect of an acute oral antioxidant cocktail (AOC, vitamins C and E, and alpha-lipoic acid) on skeletal muscle function during dynamic quadriceps exercise in COPD.
METHODS: Ten patients with COPD performed knee extensor exercise to exhaustion and isotime trials after either the AOC or placebo (PL). Pre- to postexercise changes in quadriceps maximal voluntary contractions and potentiated twitch forces (Q(tw,pot)) quantified quadriceps fatigue.
RESULTS: Under PL conditions, the plasma electron paramagnetic resonance (EPR) spectroscopy signal was inversely correlated with the forced expiratory volume in 1 s to forced vital capacity ratio (FEV1/FVC), an index of lung dysfunction (r = -0.61, P = 0.02), and maximal voluntary contraction force (r = -0.56, P = 0.04). AOC consumption increased plasma ascorbate levels (10.1 ± 2.2 to 24.1 ± 3.8 μg · mL(-1), P < 0.05) and attenuated the area under the curve of the EPR spectroscopy free radical signal (11.6 ± 3.7 to 4.8 ± 2.2 AU, P < 0.05), but it did not alter the endurance time or quadriceps fatigue. The ability of the AOC to decrease the EPR spectroscopy signal, however, was prominent in those with high basal free radicals (n = 5, PL, 19.7 ± 5.8, to AOC, 5.8 ± 4.5 AU; P < 0.05) with minimal effects in those with low levels (n = 5, PL, 1.6 ± 0.5, to AOC, 3.4 ± 1.1 AU).
DISCUSSION: These data document a relation between directly measured free radicals and lung dysfunction and the ability of the AOC to decrease oxidative stress in COPD. Acute amelioration of free radicals, however, does not appear to affect dynamic quadriceps exercise performance.
Authors:
Matthew J Rossman; H Jonathan Groot; Van Reese; Jia Zhao; Markus Amann; Russell S Richardson
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2014-02-14     Revised Date:  2014-03-11    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1235-43     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Antioxidants / pharmacology*,  therapeutic use
Ascorbic Acid / pharmacology*,  therapeutic use
Biological Markers / blood
Drug Administration Schedule
Drug Combinations
Electromyography
Electron Spin Resonance Spectroscopy
Exercise Test
Female
Free Radicals / blood
Humans
Male
Middle Aged
Muscle Fatigue / drug effects*
Oxidative Stress / drug effects*
Pulmonary Disease, Chronic Obstructive / blood,  drug therapy*,  physiopathology
Quadriceps Muscle / drug effects,  physiopathology
Respiratory Function Tests
Single-Blind Method
Thioctic Acid / pharmacology*,  therapeutic use
Treatment Outcome
Vitamin E / pharmacology*,  therapeutic use
Grant Support
ID/Acronym/Agency:
P01 HL 09830/HL/NHLBI NIH HHS; R00 HL103786/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Drug Combinations; 0/Free Radicals; 1406-18-4/Vitamin E; 73Y7P0K73Y/Thioctic Acid; PQ6CK8PD0R/Ascorbic Acid
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