| The oxidative folding and misfolding of human leukocyte antigen-b27. | |
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MedLine Citation:
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PMID: 21671754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The major histocompatibility complex class I molecule human leukocyte antigen (HLA)-B27 is strongly associated with a group of inflammatory arthritic disorders known as the spondyloarthropathies. Many autoimmune diseases exhibit associations with major histocompatibility complex molecules encoded within the class II locus with defined immune responses either mediated by T or B-lymphocytes. Despite the association being known for over 30 years, no defined immune response and target autoantigens have been characterized for the spondyloarthropathies. Thus, the mechanism and role of HLA-B27 in disease pathogenesis remains undetermined. One hypothesis that has recently received much attention has focused around the enhanced propensity for HLA-B27 to misfold and the increased tendency of the heavy chain to dimerize. The misfolding of HLA-B27 has been associated with its redox status and this is postulated to be involved in disease development. Here we discuss the impact of the redox status on HLA-B27 biosynthesis and function. |
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Authors:
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Antony N Antoniou; David B Guiliano; Izabela Lenart; Garth Burn; Simon J Powis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-06-14 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 15 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-06 Completed Date: 2011-10-28 Revised Date: 2011-12-01 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 669-84 Citation Subset: IM |
Affiliation:
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Division of Infection and Immunity/Centre of Rheumatology, Department of Immunology and Molecular Pathology, University College London, Windeyer Institute of Medical Science, London, United Kingdom. anthony.antoniou@ucl.ac.uk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cysteine
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chemistry Disulfides / chemistry HLA-B27 Antigen / chemistry, metabolism* Histocompatibility Antigens Class II / immunology Histocompatibility Testing Humans Lymphocytes / immunology Oxidation-Reduction Oxidative Stress / immunology Protein Folding Protein Multimerization / immunology Proteostasis Deficiencies / metabolism* Spondylarthropathies / metabolism* beta 2-Microglobulin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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15293//Arthritis Research UK; 17222//Arthritis Research UK; 17868//Arthritis Research UK |
| Chemical | |
Reg. No./Substance:
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0/Disulfides; 0/HLA-B27 Antigen; 0/Histocompatibility Antigens Class II; 0/beta 2-Microglobulin; 52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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