Document Detail

Oxidative DNA damage in relation to nutrition.
MedLine Citation:
PMID:  15004656     Owner:  NLM     Status:  MEDLINE    
Oxidative DNA damage in humans could arise also from incorrect nutritional habit and life style. DNA strand breaks with apurinic/apyrimidinic sites, oxidized purines and oxidized pyrimidines were assessed in 24 subjectively healthy vegetarians (plant food, dairy products, eggs) and compared with 24 non-vegetarians (traditional diet, general population). DNA strand breaks + oxidized purines are significantly reduced in vegetarians (p<0.05), DNA strand breaks are nonsignificantly decreased. The sufficient antioxidative status (overthreshold values of natural essential antioxidants, which mean a reduced risk of free radical disease) is crucial in free radical defense. Intake of protective food commodities (fruit, vegetables, dark grain products, grain sprouts, oil seeds) is significantly higher in vegetarians. Alternative nutrition subjects have a significantly increased plasma levels of vitamin C, vitamin E, beta-carotene with high incidence of overthreshold values (92% vs. 42% - vitamin C, 67% vs. 33% - vitamin E, 67% vs. 17% - beta-carotene). There is recorded a significant inverse linear correlation between values of DNA strand breaks + oxidized purines and vitamin C or beta-carotene levels (p<0.01, p<0.05). Vegetarian diet is significantly more rich source of antioxidants. The results of reduced endogenous DNA damage and higher antioxidative status in vegetarians document that a correct vegetarian nutrition might represent an effective cancer prevention.
M Krajcovicová-Kudlácková; M Dusinská
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  51     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-08     Completed Date:  2004-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  30-3     Citation Subset:  IM    
Institute of Preventive and Clinical Medicine;, Bratislava, 833 01 Slovak Republic.
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MeSH Terms
Ascorbic Acid / administration & dosage
DNA Damage*
Diet, Vegetarian*
Food Habits
Middle Aged
beta Carotene / administration & dosage
Reg. No./Substance:
50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene

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