Document Detail


Oxidative DNA damage and antioxidant defense after reperfusion in acute myocardial infarction.
MedLine Citation:
PMID:  19240647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Myocardial damage mediated by oxidative stress during acute myocardial infarction (MI) has been suggested as an obstructive factor on recovery after an MI. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker for oxidative DNA damage; superoxide dismutase (SOD) and glutathione peroxidase (G-Px) are major antioxidant enzymes. We determined changes in the plasma level of 8-OHdG and activities of SOD and G-Px in patients with MI and examined the relations between those changes and other cardiac markers. METHODS: Blood samples were taken at the beginning of the therapy, on the third day of hospitalization, and on the day patients were discharged home. Plasma level of 8-OHdG and SOD and G-Px activities were measured by enzyme-linked immunosorbent assay and spectrophotometric kits, respectively. RESULTS: 8-Hydroxydeoxyguanosine level at the beginning of the therapy was found to be decreased on the third day of therapy and on the day patients were discharged home. With respect to the treatment way, 8-OHdG level was found to be slightly decreased on the third day of therapy and then remained stable in the group treated with thrombolytic agents. However, 8-OHdG level was found to be sharply decreased on the third day of therapy in the group that underwent primary percutaneous transluminal coronary angioplasty. No significant relations were determined between those measured parameters and serum levels of cardiac markers. CONCLUSION: Although not correlated with other cardiac markers, plasma level of 8-OHdG shows a decrease after reperfusion therapy in patients with MI, and primary percutaneous transluminal coronary angioplasty seems much more effective than thrombolytic therapy for providing a low level of 8-OHdG.
Authors:
Solen Himmetoglu; Yildiz Dincer; Evin Bozcali; Vural Ali Vural; Tulay Akcay
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  57     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  595-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism*
Biological Markers / blood
DNA / genetics*
DNA Damage*
Deoxyguanosine / analogs & derivatives,  blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood*,  genetics,  surgery
Myocardial Reperfusion / methods*
Oxidative Stress / genetics*
Postoperative Period
Prognosis
Spectrophotometry
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Antioxidants; 0/Biological Markers; 9007-49-2/DNA; 961-07-9/Deoxyguanosine

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