| Oxidation of Dietary Stearic, Oleic and Linoleic Acids in Growing Pigs Follows a Biphasic Pattern. | |
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MedLine Citation:
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PMID: 21795428 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We used the pig as a model to assess the effects of dietary fat content and composition on nutrient oxidation and energy partitioning in positive energy balance. Pigs weighing 25 kg were assigned to either: 1) a low fat-high starch diet, or 2) a high saturated-fat diet, or 3) a high unsaturated-fat diet. In the high-fat treatments, 20% starch was iso-energetically replaced by 10.8% lard or 10.2% soybean oil, respectively. For 7 d, pigs were fed twice daily at a rate of 1200 kJ digestible energy ⋅ kg(-0.75) ⋅ d(-1). Oral bolus doses of [U-(13)C] glucose, [U-(13)C] α-linoleate, [U-(13)C] stearate, and [U-(13)C] oleate were administered on d 1, 2, 4, and 6, respectively, and (13)CO(2) production was measured. Protein and fat deposition were measured for 7 d. Fractional oxidation of fatty acids from the low-fat diet was lower than from the high-fat diets. Within diets, the saturated [U-(13)C] stearate was oxidized less than the unsaturated [U-(13)C] oleate and [U-(13)C] linoleate. For the high unsaturated-fat diet, oxidation of [U-(13)C] oleate was higher than that of [U-(13)C] linoleate. In general, recovery of (13)CO(2) from labeled fatty acids rose within 2 h after ingestion but peaked around the next meal. This peak was induced by an increased energy expenditure that was likely related to increased eating activity. In conclusion, oxidation of dietary fatty acids in growing pigs depends on the inclusion level and composition of dietary fat. Moreover, our data suggest that the most recently ingested fatty acids are preferred substrates for oxidation when the direct supply of dietary nutrients has decreased and ATP requirements increase. |
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Authors:
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Erik Bruininx; Joost van den Borne; Eric van Heugten; Jaap van Milgen; Martin Verstegen; Walter Gerrits |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-27 |
Journal Detail:
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Title: The Journal of nutrition Volume: - ISSN: 1541-6100 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Animal Nutrition Group, Wageningen University, Wageningen, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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