Document Detail

Oxidation of [(13)C]glycerol ingested along with glucose during prolonged exercise.
MedLine Citation:
PMID:  11299256     Owner:  NLM     Status:  MEDLINE    
The respective oxidation of glycerol and glucose (0.36 g/kg each) ingested simultaneously immediately before exercise (120 min at 68 +/- 2% maximal oxygen uptake) was measured in six subjects using (13)C labeling. Indirect respiratory calorimetry corrected for protein and glycerol oxidation was used to evaluate the effect of glucose + glycerol ingestion on the oxidation of glucose and fat. Over the last 80 min of exercise, 10.0 +/- 0.8 g of exogenous glycerol were oxidized (43% of the load), while exogenous glucose oxidation was 21% higher (12.1 +/- 0.7 g or 52% of the load). However, because the energy potential of glycerol is 18% higher than that of glucose (4.57 vs. 3.87 kcal/g), the contribution of both exogenous substrates to the energy yield was similar (4.0-4.1%). Total glucose and fat oxidation were similar in the placebo (144.4 +/- 13.0 and 60.5 +/- 4.2 g, respectively) and the glucose + glycerol (135.2 +/- 12.0 and 59.4 +/- 6.5 g, respectively) trials, whereas endogenous glucose oxidation was significantly lower than in the placebo trial (123.7 +/- 11.7 vs. 144.4 +/- 13.0 g). These results indicate that exogenous glycerol can be oxidized during prolonged exercise, presumably following conversion into glucose in the liver, although direct oxidation in peripheral tissues cannot be ruled out.
Y Burelle; D Massicotte; M Lussier; C Lavoie; C Hillaire-Marcel; F Péronnet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  90     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-07-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1685-90     Citation Subset:  IM    
Département de Kinésiologie, Université de Montréal, CP 6128 Centre Ville, Montréal H3C 3J7, Canada G9A 5H7.
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MeSH Terms
Administration, Oral
Breath Tests
Calorimetry, Indirect / methods
Carbon Dioxide / analysis
Carbon Isotopes
Exercise / physiology*
Glucose / administration & dosage,  metabolism*
Glycerol / administration & dosage,  metabolism*
Oxygen Consumption*
Physical Exertion / physiology*
Reg. No./Substance:
0/Carbon Isotopes; 124-38-9/Carbon Dioxide; 50-99-7/Glucose; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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