Document Detail


Oxidase-like activity of polymer-coated cerium oxide nanoparticles.
MedLine Citation:
PMID:  19130532     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).
Authors:
Atul Asati; Santimukul Santra; Charalambos Kaittanis; Sudip Nath; J Manuel Perez
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  48     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-04-30     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2308-12     Citation Subset:  IM    
Affiliation:
Nanoscience Technology Center, Department of Chemistry and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.
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MeSH Terms
Descriptor/Qualifier:
Catalysis
Cell Line, Tumor
Cerium / chemistry*
Fluorescent Dyes / chemistry
Humans
Kinetics
Metal Nanoparticles / chemistry*
Oxidation-Reduction
Oxidoreductases / metabolism
Polymers / chemistry*
Grant Support
ID/Acronym/Agency:
CA101781/CA/NCI NIH HHS; K01 CA101781-05/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; 0/Polymers; 619G5K328Y/ceric oxide; 7440-45-1/Cerium; EC 1.-/Oxidoreductases
Comments/Corrections

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