Document Detail

Oxidase-like activity of polymer-coated cerium oxide nanoparticles.
MedLine Citation:
PMID:  19130532     Owner:  NLM     Status:  MEDLINE    
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).
Atul Asati; Santimukul Santra; Charalambos Kaittanis; Sudip Nath; J Manuel Perez
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  48     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-04-30     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2308-12     Citation Subset:  IM    
Nanoscience Technology Center, Department of Chemistry and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.
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MeSH Terms
Cell Line, Tumor
Cerium / chemistry*
Fluorescent Dyes / chemistry
Metal Nanoparticles / chemistry*
Oxidoreductases / metabolism
Polymers / chemistry*
Grant Support
CA101781/CA/NCI NIH HHS; K01 CA101781-05/CA/NCI NIH HHS
Reg. No./Substance:
0/Fluorescent Dyes; 0/Polymers; 619G5K328Y/ceric oxide; 7440-45-1/Cerium; EC 1.-/Oxidoreductases

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