Document Detail

Oxidants, metabolism, and stem cell biology.
MedLine Citation:
PMID:  22041454     Owner:  NLM     Status:  MEDLINE    
Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.
Jie Liu; Liu Cao; Toren Finkel
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-18
Journal Detail:
Title:  Free radical biology & medicine     Volume:  51     ISSN:  1873-4596     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-25     Completed Date:  2012-05-18     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2158-62     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
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MeSH Terms
Cell Physiological Processes
Oxidants / metabolism*
Stem Cells / cytology,  metabolism*
Grant Support
Reg. No./Substance:

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