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Oxidants, antioxidants, and respiratory tract lining fluids.
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MedLine Citation:
PMID:  7705296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidant contained in the RTLFs can be expected to provide an initial defense against inhaled environmental toxins. The major antioxidants in RTLF include mucin, uric acid, protein (largely albumin), ascorbic acid, and reduced glutathione (GSH). RTLF antioxidants can be augmented by such processes as transudation/exudation of plasma constituents; RTEC secretory processes, including glandular mucus secretion; and cellular antioxidants derived from lysis of RTECs and of inflammatory cells. The antioxidant composition of RTLFs and their role in modulating normal and pathophysiologic RTEC functions under conditions of oxidative stress are yet to be fully characterized.
Authors:
C E Cross; A van der Vliet; C A O'Neill; S Louie; B Halliwell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  102 Suppl 10     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-10     Completed Date:  1995-05-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Affiliation:
University of California-Davis Medical Center, Sacramento 95817.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism*
Blood / drug effects
Body Fluids / chemistry,  metabolism*
Humans
Oxidants / pharmacology*
Respiratory System / metabolism*
Grant Support
ID/Acronym/Agency:
ES 00628/ES/NIEHS NIH HHS; HL 47628/HL/NHLBI NIH HHS; RR-00169/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Oxidants
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 12 Year: 1994
Volume: 102 Issue: Suppl 10
First Page: 185 Last Page: 191
ID: 1566988
PubMed Id: 7705296

Oxidants, antioxidants, and respiratory tract lining fluids.
C E Cross
A van der Vliet
C A O'Neill
S Louie
B Halliwell
University of California-Davis Medical Center, Sacramento 95817.



Article Categories:
  • Research Article


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