Document Detail

Oxidant stress responses in premature infants during exposure to hyperoxia.
MedLine Citation:
PMID:  8134179     Owner:  NLM     Status:  MEDLINE    
To assess oxidant stress responses in newborn infants treated with elevated concentrations of oxygen, we measured plasma concentrations of glutathione (GSH) and glutathione disulfide (GSSG) in newborn infants ranging from 23 to 42 wk gestational age. All infants recruited into the study were mechanically ventilated and had catheters placed in their umbilical arteries as part of their normal clinical management. Blood samples were obtained on d 1, 3, and 5 and weekly thereafter or until the catheters were removed. We observed plasma concentrations of GSSG in these infants that were frequently an order of magnitude higher than the 0.1 to 0.3 microM we find in adults. Interestingly, plasma GSSG concentrations were inversely correlated to the inspired oxygen tensions. This effect appeared to arise from the patient selection criteria whereby, of the infants studied, those breathing the lowest partial pressures of oxygen were the smallest and gestationally youngest. A second observation was that plasma concentrations of GSH in the premature infants were substantially, indeed often dramatically, lower than we have observed in adult humans (6 to 10 microM). Finally, we found that in patients with both umbilical arterial and umbilical venous catheters arterial GSSG concentrations were consistently higher than venous concentrations; conversely, arterial GSH concentrations were lower than venous concentrations. The elevated GSSG concentrations we observed in these infants indicate marked oxidant stress responses in prematurely born infants, even in those infants exposed only to room air. The positive arteriovenous gradients of GSSG concentrations across the lungs of these infants suggest that at least some of the increased plasma GSSG originates in the lung.(ABSTRACT TRUNCATED AT 250 WORDS)
C V Smith; T N Hansen; N E Martin; H W McMicken; S J Elliott
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  34     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-04-18     Completed Date:  1994-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  360-5     Citation Subset:  IM    
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
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MeSH Terms
Biological Markers / blood
Birth Weight
Gestational Age
Glutathione / blood*
Hypertension, Pulmonary / blood,  complications,  congenital,  drug therapy
Infant, Newborn
Infant, Premature / blood*
Oxygen / adverse effects*,  therapeutic use
Prospective Studies
Respiration Disorders / blood,  complications,  congenital,  drug therapy
Respiration, Artificial
Stress, Physiological / blood*,  etiology
Umbilical Arteries
Umbilical Veins
Grant Support
Reg. No./Substance:
0/Biological Markers; 70-18-8/Glutathione; 7782-44-7/Oxygen

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