| Oxidant-mediated proteolytic activation of Ca(+)-ATPase in microsomes of pulmonary smooth muscle. | |
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MedLine Citation:
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PMID: 8674543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of bovine pulmonary artery smooth muscle tissue microsomes with H2O2 (1 mM) markedly stimulated protease activity tested with a synthetic substrate N-benzoyl-DL-arginine p-nitroanilide (BAPNA), and also enhanced Ca(2+)-ATPase activity. ATP-dependent Ca(2+) uptake was found to be stimulated upon treatment of the microsomes with H2O2. Pretreatment of the microsomes with vitamin E and aprotinin prevented the H2O2-induced stimulation of Ca(2+)-ATPase activity and also ATP-dependent Ca(2+) uptake. In contrast, H2O2-induced inhibition of Na(+)-dependent Ca(2+) uptake was reversed by vitamin E and aprotinin. |
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Authors:
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S K Ghosh; T Chakraborti; J R Michael; S Chakraborti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 387 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-08-15 Completed Date: 1996-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 171-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, University of Kalyani, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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5'-Nucleotidase
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metabolism Acid Phosphatase / metabolism Animals Aprotinin / pharmacology Calcium / metabolism Calcium-Transporting ATPases / drug effects, metabolism* Cattle Electron Transport Complex IV / metabolism Enzyme Activation Hydrogen Peroxide / pharmacology* Microsomes / drug effects, enzymology* Muscle, Smooth, Vascular / enzymology* NADH, NADPH Oxidoreductases / metabolism NADPH-Ferrihemoprotein Reductase Oxidants / pharmacology* Pulmonary Artery Vitamin E / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Oxidants; 1406-18-4/Vitamin E; 7440-70-2/Calcium; 7722-84-1/Hydrogen Peroxide; 9087-70-1/Aprotinin; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.2.4/NADPH-Ferrihemoprotein Reductase; EC 1.9.3.1/Electron Transport Complex IV; EC 3.1.3.2/Acid Phosphatase; EC 3.1.3.5/5'-Nucleotidase; EC 3.6.1.8/Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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