Document Detail

Oxidant generation capacity of source-apportioned PM2.5.
MedLine Citation:
PMID:  20843277     Owner:  NLM     Status:  MEDLINE    
While many studies found associations between ambient particulate matter (PM) and morbidity or mortality outcomes, it is unclear whether these associations were dependent on the composition of PM, which varies with the source of that PM. We address this knowledge gap by conducting a time-series PM-health effects assessment that specifically investigates the role of source-apportioned fine PM (PM2.5) on the oxidant generation capacity that might be responsible for respiratory and cardiovascular health outcomes. Daily PM2.5 composition speciation and black carbon (BC) measurements, conducted in rural New York for 303 days between March 2003 and January 2005, were analyzed using factor analysis source-apportionment model, and five source categories (transported aerosol/secondary sulfate, resuspended soil, metals, residual oil combustion, and industrial/incineration) were identified. After the exposure of human epithelial cells (BEAS-2B) to these PM2.5 samples, cellular nuclear factor-κB (NF-κB) activation showed a relatively significant association Ni (concentration averaging 38 ng/m(3)), and weaker but still significant correlations with Ba (13 ng/m(3)), Mn (9 ng/m(3)), and Fe (500 ng/m(3)). The single-source regression analysis of NF-κB signal showed significant association with metal source only. Our results showed that metals in PM2.5 were the important source for cellular oxidant generation and may be responsible for subsequent health effects associate with particle air pollution.
Polina Maciejczyk; Mianhua Zhong; Morton Lippmann; Lung-Chi Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-09-16
Journal Detail:
Title:  Inhalation toxicology     Volume:  22 Suppl 2     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-24     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
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MeSH Terms
Air Pollutants / analysis*
Air Pollution / analysis*
Cells, Cultured
Environmental Monitoring*
Epithelial Cells / metabolism
Metals / analysis
NF-kappa B / metabolism
New York
Oxidants / metabolism*
Particulate Matter / analysis*
Regression Analysis
Grant Support
Reg. No./Substance:
0/Aerosols; 0/Air Pollutants; 0/Metals; 0/NF-kappa B; 0/Oxidants; 0/Particulate Matter

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