Document Detail


Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunction.
MedLine Citation:
PMID:  18705676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To collect data on sexual dysfunction in a larger population of male patients with epilepsy treated with oxcarbazepine in a naturalistic setting.
PATIENTS AND METHODS: Six hundred seventy-three adult male patients with partial epilepsy in whom monotherapy with oxcarbazepine was indicated were evaluated at baseline and after approximately 12 weeks of treatment with regard to the number of seizures and occurrence of any adverse drug reactions. All patients were questioned regarding their sexual function.
RESULTS: Out of 228 patients with pre-existing sexual function impairment at baseline, an improvement was observed in 181 (79.4%) patients, 23 (10.1%) patients experienced no impairment at the final visit. The improvements were more marked in those patients, who were pretreated with enzyme-inducing antiepileptic drugs. No worsening of the sexual dysfunction was observed.
CONCLUSIONS: Oxcarbazepine was found to have beneficial effects on sexual dysfunction and to be effective and well tolerated in male patients with partial epilepsy.
Authors:
G Luef; G Krämer; H Stefan
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Publication Detail:
Type:  Journal Article     Date:  2008-08-14
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  119     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-02-05     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria. gerhard.luef@i-med.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anticonvulsants / therapeutic use*
Carbamazepine / adverse effects,  analogs & derivatives*,  therapeutic use
Ejaculation / drug effects
Epilepsies, Partial / complications*,  drug therapy*
Erectile Dysfunction / complications,  drug therapy
Humans
Interviews as Topic
Libido / drug effects
Male
Middle Aged
Sexual Dysfunction, Physiological / complications*,  drug therapy*,  physiopathology
Young Adult
Chemical
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine; VZI5B1W380/oxcarbazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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