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Oxcarbazepine-induced myoclonic status epilepticus in juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  23774821     Owner:  NLM     Status:  Publisher    
Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be underdiagnosed or misdiagnosed; in the latter case, it may be mistaken for partial epilepsy. The incorrect diagnosis of JME is likely to result in inappropriate therapy, which may, in turn, worsen the seizures. While a number of studies have documented that carbamazepine aggravates idiopathic generalised epilepsy, few have shown a worsening of symptoms following the administration of oxcarbazepine (OXC). We report the case of a 44-year-old male affected by JME in which the inappropriate use of OXC precipitated a dramatic worsening of myoclonic seizures. In this case, video-EEG monitoring documented myoclonic status epilepticus with positive and negative myoclonus, correlating with repetitive, continuous, rhythmic, generalised polyspike-and-wave discharges. This is the first case of myoclonic status epilepticus induced by OXC in a patient with JME which is clearly documented by video-EEG. A review of the literature with regards to OXC-induced worsening of seizures is also presented. [Published with video sequences].
Martina Fanella; Gabriella Egeo; Jinane Fattouch; Sara Casciato; Leonardo Lapenta; Alessandra Morano; Anna Teresa Giallonardo; Carlo Di Bonaventura
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-17
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  -     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurology and Psychiatry, Epilepsy Unit, Sapienza University of Rome.
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