| Oxcarbazepine-induced Stevens-Johnson syndrome: a case report. | |
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MedLine Citation:
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PMID: 19321411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although carbamazepine (CBZ) is the most common cause of Stevens-Johnson syndrome (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA) B*1502 and CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA-B*1518/B*4001. HLA-B*1518 is a HLA-B15 variant. The genetic significance of HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further studied. |
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Authors:
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Lung-Chang Lin; Ping-Chin Lai; Sheau-Fang Yang; Rei-Cheng Yang |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Kaohsiung journal of medical sciences Volume: 25 ISSN: 1607-551X ISO Abbreviation: Kaohsiung J. Med. Sci. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-03-26 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960562 Medline TA: Kaohsiung J Med Sci Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 82-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects* Carbamazepine / adverse effects, analogs & derivatives* Child Epidermal Necrolysis, Toxic / etiology Genotype HLA-B Antigens / genetics Humans Male Stevens-Johnson Syndrome / chemically induced*, genetics, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/HLA-B Antigens; 0/HLA-B15; 28721-07-5/oxcarbazepine; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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