Document Detail


Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone.
MedLine Citation:
PMID:  6626439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics and serum protein binding of oxazepam, a drug mainly eliminated by a single step glucuronidation reaction, were studied in nine epileptic patients treated long-term with phenytoin or phenytoin with phenobarbitone, and in nine healthy control subjects. Oxazepam elimination half-life was shorter and apparent oral clearance higher in treated patients than in age and sex matched control subjects. Serum bilirubin concentration was lower in treated patients. There was no significant correlation between serum bilirubin concentrations and oxazepam elimination. Serum alpha 1-acid glycoprotein concentration was higher in the treated patients than in the control group. Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups. These results show that oxazepam glucuronyl transferase activity is increased by treatment with phenytoin alone or in combination with phenobarbitone in epileptic patients.
Authors:
A K Scott; A S Khir; W H Steele; G M Hawksworth; J C Petrie
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  16     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-21     Completed Date:  1983-12-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  441-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bilirubin / blood
Dialysis
Drug Interactions
Epilepsy / drug therapy,  metabolism*
Female
Humans
Kinetics
Male
Middle Aged
Oxazepam / metabolism*
Phenobarbital / adverse effects*,  therapeutic use
Phenytoin / adverse effects*,  therapeutic use
Protein Binding
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital; 57-41-0/Phenytoin; 604-75-1/Oxazepam; 635-65-4/Bilirubin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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