Document Detail


Oxandrolone enhances hepatic ketogenesis in adult men.
MedLine Citation:
PMID:  18797410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein. RATIONALE FOR THE STUDY: We postulated that oxandrolone should increase hepatic lipase and that the nonesterified fatty acids generated would enhance hepatic ketogenesis during an extended fat tolerance test. MAIN RESULTS: Eighteen men participated in the study using short-term administration of oxandrolone (10 mg/d) over a week. Subjects had evaluation of hepatic ketogenesis at baseline and after 7 days of administration of oxandrolone. Ketogenesis was assessed by measuring plasma levels of 3-hydroxybutyrate during a fat tolerance test. Oxandrolone increased fasting levels of 3-hydroxybutyrate by 70%, and increased the area under the curve during an FFT by 53% above pretreatment levels without affecting the areas under the curve for nonesterified fatty acids, glycerol, or triglycerides. Fasting 3-hydroxybutyrate levels correlated with nonesterified fatty acids and with triglycerides; however, there were no significant correlations with any other parameter. CONCLUSIONS: This study shows that short-term administration of oxandrolone results in marked increases in hepatic ketogenesis. This finding is consistent with an increased influx of fatty acids into the liver secondary to lipoprotein lipolysis by increased hepatic lipase. However, the possibility cannot be ruled out that oxandrolone acts directly in the liver to stimulate fatty acid oxidation. Therefore, the observation of increased ketogenesis will require further studies to determine the molecular basis of the response.
Authors:
Gloria Lena Vega; Jacob J Clarenbach; Fredrick Dunn; Scott M Grundy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  56     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-03     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  920-4     Citation Subset:  IM    
Affiliation:
Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Gloria.Vega@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxybutyric Acid / blood
Anabolic Agents / administration & dosage,  pharmacology
Fatty Acids / metabolism
Humans
Ketones / metabolism*
Lipase / metabolism
Lipolysis / drug effects
Liver / drug effects*,  metabolism*
Male
Middle Aged
Oxandrolone / administration & dosage,  pharmacology*
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Fatty Acids; 0/Ketones; 300-85-6/3-Hydroxybutyric Acid; 53-39-4/Oxandrolone; EC 3.1.1.3/Lipase; EC 3.1.1.3/hepatic lipase, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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