Document Detail

Oxalate-induced and cell-cycle-dependent expression of nuclear pore complex oxalate binding protein gp210.
MedLine Citation:
PMID:  10581167     Owner:  NLM     Status:  MEDLINE    
The effect of oxalate, a constituent of renal stone, on the expression of nuclear pore complex oxalate binding protein (gp210) in Vero monkey kidney cells was examined. The expression of this protein was found to increase more in mitotic phase than in S phase, suggesting cell cycle dependency. Exposure of cells to oxalate-containing growth medium resulted in a relative increase in nuclear pore complex oxalate binding protein in each stage of cell cycle. The concentration of this protein was found to increase six times in the telophase stage of the cells exposed to high concentrations of oxalate in the growth medium, though slight reduction in cell density was observed. Structural analogues of oxalate did not show any stimulatory effect on expression of this oxalate binding protein. Hence, the expression of the nuclear pore complex oxalate binding protein gp210 was specific to oxalate and is cell cycle dependent.
R Vijaya; M Kannapiran; R Selvam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  266     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  72-5     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Department of Medical Biochemistry, Dr. Alm Post Graduate Institute of Basic Medical Sciences, Chennai, 600113, India.
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MeSH Terms
Cell Count / drug effects
Cell Cycle / physiology*
Cercopithecus aethiops
Citric Acid / pharmacology
Dose-Response Relationship, Drug
Gene Expression Regulation / drug effects*
Malates / pharmacology
Membrane Glycoproteins / metabolism*
Nuclear Envelope / drug effects,  metabolism*
Nuclear Proteins / metabolism*
Oxalates / pharmacology*
Oxamic Acid / pharmacology
Succinic Acid / pharmacology
Vero Cells
Reg. No./Substance:
0/Malates; 0/Membrane Glycoproteins; 0/Nuclear Proteins; 0/Oxalates; 110-15-6/Succinic Acid; 471-47-6/Oxamic Acid; 6915-15-7/malic acid; 77-92-9/Citric Acid

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