Document Detail


Oxacillin prophylaxis in cerebrospinal fluid shunt procedures: results of a randomized open study in 60 hydrocephalic patients.
MedLine Citation:
PMID:  3510475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 27-month open randomized trial (October 1981-January 1984) was carried out to study the prophylactic efficacy of antibiotics in 60 hydrocephalic patients being shunted for the first time. The treatment group received oxacillin at a dosage of 200 mg/kg/day by six bolus intravenous injections, beginning with anesthetic induction and continuing for 24 hours after the operations. The minimum postoperative observation was 6 months. Six patients in the control group developed cerebrospinal fluid infections (20%) as compared with only a single patient in the oxacillin group (3.3%); this difference was statistically significant (p less than 0.05). Time of development of cerebrospinal fluid infection was brief (86% at 6 weeks), and as usual staphylococci were the pathogens most frequently implicated. This study would appear to confirm the choice of oxacillin for prevention of meningitis. Nevertheless, the frequency of methicillin-resistant staphylococci, which account for 20% of nosocomial staphylococcal infections, constitutes a limiting factor for such prevention.
Authors:
M Djindjian; M J Fevrier; G Otterbein; J C Soussy
Related Documents :
20467465 - A single-institution review of portosystemic shunts in children: an ongoing discussion.
8208945 - Variceal hemorrhage: efficacy of transjugular intrahepatic portosystemic shunts created...
9066565 - Peritoneovenous shunting for malignant ascites.
17039525 - Transcatheter closure versus medical therapy of patent foramen ovale and cryptogenic st...
23234955 - Longitudinal comparison of inflammatory, coagulation and metabolic biomarkers in patien...
3194905 - Surgical closure of ventricular septal defect in the first year of life: forty-three co...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Surgical neurology     Volume:  25     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-02-18     Completed Date:  1986-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acinetobacter Infections / etiology,  prevention & control
Adolescent
Adult
Cerebrospinal Fluid Shunts* / adverse effects
Child
Clinical Trials as Topic
Humans
Hydrocephalus / surgery
Middle Aged
Oxacillin / therapeutic use*
Prospective Studies
Random Allocation
Staphylococcal Infections / etiology,  prevention & control*
Chemical
Reg. No./Substance:
66-79-5/Oxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Conservative surgery in Crohn disease.
Next Document:  "Closed-open" arterial embolectomy.