Document Detail

Oxacillin prophylaxis in cerebrospinal fluid shunt procedures: results of a randomized open study in 60 hydrocephalic patients.
MedLine Citation:
PMID:  3510475     Owner:  NLM     Status:  MEDLINE    
A 27-month open randomized trial (October 1981-January 1984) was carried out to study the prophylactic efficacy of antibiotics in 60 hydrocephalic patients being shunted for the first time. The treatment group received oxacillin at a dosage of 200 mg/kg/day by six bolus intravenous injections, beginning with anesthetic induction and continuing for 24 hours after the operations. The minimum postoperative observation was 6 months. Six patients in the control group developed cerebrospinal fluid infections (20%) as compared with only a single patient in the oxacillin group (3.3%); this difference was statistically significant (p less than 0.05). Time of development of cerebrospinal fluid infection was brief (86% at 6 weeks), and as usual staphylococci were the pathogens most frequently implicated. This study would appear to confirm the choice of oxacillin for prevention of meningitis. Nevertheless, the frequency of methicillin-resistant staphylococci, which account for 20% of nosocomial staphylococcal infections, constitutes a limiting factor for such prevention.
M Djindjian; M J Fevrier; G Otterbein; J C Soussy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Surgical neurology     Volume:  25     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-02-18     Completed Date:  1986-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-80     Citation Subset:  IM    
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MeSH Terms
Acinetobacter Infections / etiology,  prevention & control
Cerebrospinal Fluid Shunts* / adverse effects
Clinical Trials as Topic
Hydrocephalus / surgery
Middle Aged
Oxacillin / therapeutic use*
Prospective Studies
Random Allocation
Staphylococcal Infections / etiology,  prevention & control*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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