Document Detail

Ovulation induction in polycystic ovary syndrome: No. 242, May 2010.
MedLine Citation:
PMID:  20848729     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review current non-pharmacologic and pharmacologic options for ovulation induction in women with polycystic ovary syndrome (PCOS).
OPTIONS: This guideline reviews the evidence for the various options for ovulation induction in PCOS.
OUTCOMES: Ovulation, pregnancy and live birth rates, risks, and side effects are the outcomes of interest.
EVIDENCE: Published literature was retrieved through searches of Medline using appropriate controlled vocabulary and key words. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Grey (unpublished) literature was identified through searching the websites of health technology assessment and of health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.
VALUES: The evidence gathered was reviewed and evaluated by the Reproductive Endocrinology and Infertility Committee of the Society of Obstetricians and Gynaecologists of Canada. The quality of evidence was quantified using the Canadian Task Force on Preventive Health Care.
BENEFITS, HARMS, AND COSTS: Benefits include weight reduction and improvements in ovulation, pregnancy, and live birth rates. Potential harms include medication side effects and multiple pregnancies.
VALIDATION: These guidelines have been reviewed and approved by the Reproductive Endocrinology and Infertility Committee of the SOGC.
Tannys D R Vause; Anthony P Cheung; Sony Sierra; Paul Claman; James Graham; Jo-Anne Guillemin; Louise Lapensée; Sabrina Steward; Benjamin Chee-Man Wong;
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Publication Detail:
Type:  Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  111     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2010-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
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MeSH Terms
Aromatase Inhibitors / therapeutic use*
Clomiphene / therapeutic use*
Fertility Agents, Female / therapeutic use*
Fertilization in Vitro
Gonadotropins / therapeutic use*
Hypoglycemic Agents / therapeutic use*
Infertility, Female / drug therapy*,  surgery
Metformin / therapeutic use*
Ovary / surgery
Ovulation Induction / methods*
Polycystic Ovary Syndrome / drug therapy*
Randomized Controlled Trials as Topic
Weight Loss
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Fertility Agents, Female; 0/Gonadotropins; 0/Hypoglycemic Agents; 657-24-9/Metformin; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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