| Ovulation induction in normogonadotropic anovulation (PCOS). | |
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MedLine Citation:
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PMID: 16772156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of normogonadotropic anovulatory infertility (World Health Organization class 2, or WHO2) is by induction of ovulation using clomiphene citrate (CC), followed by follicle-stimulating hormone (FSH) in cases of treatment failure. Not all patients will become ovulatory or will conceive with this treatment. Others, exhibiting multifollicular instead of monofollicular development, may encounter complications such as ovarian hyperstimulation and multiple pregnancy. Recently introduced alternative treatment interventions-such as insulin-sensitizing drugs, aromatase inhibitors, or laparoscopic electrocautery of the ovaries-may offer the possibility of improving the efficacy of the classical ovulation induction algorithm. Based on initial patient characteristics, it may be possible to identify specific patient subgroups with altered chances of success or complications while using one of these interventions. Regarding CC and FSH ovulation induction, this has been performed using multivariate prediction models. This approach may enable us to improve safety, cost-effectiveness, and patient convenience in future ovulation induction. |
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Authors:
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Evert J P van Santbrink; Bart C J M Fauser |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical endocrinology & metabolism Volume: 20 ISSN: 1521-690X ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-14 Completed Date: 2006-08-11 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 261-70 Citation Subset: IM |
Affiliation:
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Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. e.vansantbrink@erasmusmc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anovulation
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drug therapy* Aromatase Inhibitors / therapeutic use Clomiphene / therapeutic use Drug Administration Schedule Electrocoagulation Female Follicle Stimulating Hormone / administration & dosage, therapeutic use Humans Hypoglycemic Agents / therapeutic use Laparoscopy Ovulation Induction / methods* Polycystic Ovary Syndrome / drug therapy* Pregnancy Pregnancy Rate Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Aromatase Inhibitors; 0/Hypoglycemic Agents; 9002-68-0/Follicle Stimulating Hormone; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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