Document Detail

Ovulation induction in the nonestrogenized patient.
MedLine Citation:
PMID:  8988525     Owner:  NLM     Status:  MEDLINE    
Women with nonestrogenized amenorrhea comprise a wide array of clinical problems. Identification and correction of the underlying pathologic process is the most appropriate approach to ovulation induction. Patients with central nervous system (CNS) or hypothalamic amenorrhea are treated with pulsatile gonadotropin-releasing hormone (GnRH) when it is not possible to correct the underlying causes of these disorders. Gonadotropin therapy is needed for pituitary-related amenorrhea after conservative therapy is unsuccessful. However, ovarian hyperstimulation and multiple pregnancies are risks of gonadotropin therapy. The outcome is poor for ovarian failure or gonadotropin-resistant ovaries. An occasional pregnancy is established, but oocyte donation or adoption should be an early consideration. Women with nonestrogenized amenorrhea and a low or normal follicle-stimulating hormone (FSH) level can expect high ovulation and pregnancy rates with gonadotropin therapy when more conservative means are unsuccessful: Treatment is not likely to benefit those with elevated FSH levels.
B S Hurst
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in reproductive endocrinology     Volume:  14     ISSN:  0734-8630     ISO Abbreviation:  Semin. Reprod. Endocrinol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-26     Completed Date:  1997-03-26     Revised Date:  2006-03-13    
Medline Journal Info:
Nlm Unique ID:  8308354     Medline TA:  Semin Reprod Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-308     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Colorado, Health Sciences Center, Denver 80262, USA.
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MeSH Terms
Amenorrhea / etiology,  physiopathology*,  therapy*
Estrogens / physiology*
Ovulation Induction* / methods
Reg. No./Substance:

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