Document Detail


Ovine maternal and fetal plasma oxytocin concentrations before and during parturition.
MedLine Citation:
PMID:  7472272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the relationships between fetal and maternal oxytocin (OT) levels and the initiation of labor in sheep, paired maternal and fetal plasma OT concentrations (microunits per ml) were measured by RIA. Samples were obtained daily from pregnant ewes and their fetuses for 5 days before spontaneous delivery and frequently during the first and second stages of labor and during the 3 h after delivery. The mean maternal plasma OT concentration during the first stage of labor was not different from that preceding labor. In contrast, the mean maternal plasma OT level during stage 2 of labor was significantly higher than the earlier baseline maternal values or the mean paired fetal concentration. There was no significant increase in the mean fetal plasma OT concentration before delivery. The newborn plasma OT concentration was elevated 15 min after delivery. From these data, we conclude that in the sheep, 1) the onset of labor is not associated with increased maternal plasma OT levels, 2) cervical or vaginal distension may be the stimulus for maternal OT release during stage 2 of labor, 3) an increase in the fetal plasma OT concentration does not occur before the initiation of labor or during the course of labor, and 4) stress in the final moments of labor or in early neonatal life may be responsible for elevated cord and early neonatal plasma OT levels.
Authors:
T H Glatz; R E Weitzman; R J Eliot; A H Klein; P W Nathanielsz; D A Fisher
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  108     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1328-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Delivery, Obstetric
Female
Fetal Blood / analysis*
Kinetics
Labor, Obstetric*
Oxytocin / blood*
Postpartum Period
Pregnancy
Sheep
Grant Support
ID/Acronym/Agency:
12274//PHS HHS
Chemical
Reg. No./Substance:
50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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