| Ovine fetal placental lactate exchange and decarboxylation at midgestation. | |
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MedLine Citation:
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PMID: 8447388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a study of the metabolic implications of the large placental-to-fetal mass ratio that characterizes early fetal development, fetal plasma lactate disposal rate and CO2 production from fetal plasma lactate by fetus and placenta were measured in six midgestation (71-80 days) pregnant sheep. A constant fetal intravenous infusion of L-[U-14C]lactate and 3H2O was given to establish fetal steady-state lactate specific activity and to measure uterine and umbilical blood flows. Fetal and placental weights were 158.6 +/- 19.7 and 441.9 +/- 32.7 g, respectively. There was a significant net lactate flux into the uterine circulation (31 +/- 4.3 mumol/min, P < 0.01) but no measurable umbilical uptake. Fetal plasma lactate disposal rate was 21.2 +/- 2.7 mumol/min, approximately one-half of which represented fetal lactate flux into the placenta (9.9 +/- 1.9 mumol/min). The oxidation rate of tracer lactate carbon to 14CO2 by placenta plus fetus was 72.6 +/- 4.7% of the infused tracer and was fairly evenly distributed between the placenta and the fetus (42.4 +/- 3.9 vs. 30.3 +/- 2.2%). The midgestation placenta metabolizes and produces fetal plasma lactate at rapid and nearly equal rates. This contrasts with the late-gestation placenta, which makes a small contribution to fetal lactate disposal and is a major net source of fetal lactate. |
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Authors:
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B S Carter; R R Moores; F C Battaglia; G Meschia |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 264 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-04-02 Completed Date: 1993-04-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E221-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Colorado School of Medicine, Denver 80262. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / blood, metabolism Decarboxylation Female Fetus / metabolism* Gestational Age Lactates / metabolism* Lactic Acid Maternal-Fetal Exchange* Osmolar Concentration Placenta / metabolism* Pregnancy Pregnancy, Animal / metabolism* Sheep |
| Grant Support | |
ID/Acronym/Agency:
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HD-00781/HD/NICHD NIH HHS; HD-01866/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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