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Ovine blood: establishment of a list of reference values relevant for blood coagulation in sheep.
MedLine Citation:
PMID:  22210653     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Ovine animal models are widely used to conduct preclinical studies, e.g., to evaluate cardiovascular prostheses intended to be applied in man. However, although analyzed in many of those studies, information about ovine blood reference values is scanty. The aim of this study is to establish a reference list of ovine blood parameters relevant for blood coagulation. A cohort of 47 mature ewes was evaluated. Parameters comprised the following: cells and cellular components-platelet, red, and white cell counts (including subsets), hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV), and MCH concentration (MCHC); global tests of coagulation-prothrombin time (Quick's time) and activated partial thromboplastin time (aPTT); and parameters relevant for blood coagulation-fibrinogen, antithrombin (AT), and von Willebrand Factor. After explorative data analysis, a list of ovine reference values was established. Interestingly, a comparison with human reference values revealed some interspecies differences between sheep and man, i.e., much higher ovine ranges for some cell counts (neutrophils, lymphocytes, basophils, eosinophils, and platelets) but lower values for some other parameters (Hb, HCT, MCV, MCH, AT, and Quick's test). We established a reference list of ovine blood count and blood coagulation parameters. Because of some peculiarities of the ovine blood, this list may have implications for the interpretation of experimental data.
Authors:
Mathias H Wilhelmi; Andreas Tiede; Omke E Teebken; Theodosios Bisdas; Axel Haverich; Reinhard Mischke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  58     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Affiliation:
*Department for Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover, Germany †Center of Competence for Cardiovascular Implants-Medimplant, Hannover, Germany ‡Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany §Small Animal Clinic, Hannover School of Veterinary Medicine, Hannover, Germany.
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