| Overweight status and intrauterine exposure to gestational diabetes are associated with children's metabolic health. | |
| | |
MedLine Citation:
|
PMID: 22308218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Offspring of women with gestational diabetes (OGD) have greater risk for obesity and impaired metabolic health. Whether impaired metabolic health occurs in the absence of obesity is not clear. The purpose of this study was to investigate the independent and interactive effects of intrauterine exposure to gestational diabetes and of children's current weight status on their metabolic health. METHODS: Children aged 5-10 years (N=51) with and without intrauterine exposure to gestational diabetes (OGD vs CTRL) were grouped into normal weight (BMI<85(th) %) and overweight (BMI>85(th) %) according to Centers for Disease Control growth curves. Lipid profile was obtained by fasting blood draw, insulin sensitivity (S(I)) and secretion by liquid meal tolerance test, and body composition by dual-energy X-ray absorptiometry. RESULTS: Despite similar average BMI percentiles among normal weight OGD vs CTRL, and overweight OGD vs CTRL, OGD had greater total %fat and trunk fat adjusted for leg fat compared to CTRL (P<0.05). Overweight children had lower S(I) (P<0.05) and greater basal, static, and total insulin secretion independent of S(I) (P<0.05). OGD was independently associated with greater static insulin secretion (P<0.05) and the interaction between OGD and overweight was associated with greater basal insulin secretion independent of S(I) (P<0.01). OGD and overweight were each associated with lower HDL-C (P<0.05). CONCLUSION: Intrauterine exposure to gestational diabetes was associated with greater central adiposity and insulin secretion, and lower HDL-C, irrespective of current weight status. Future research should examine respective contributions of the intrauterine environment and of underlying genotype on children's metabolic health. |
| | |
Authors:
|
Paula C Chandler-Laney; Nikki C Bush; Wesley M Granger; Dwight J Rouse; Melissa S Mancuso; Barbara A Gower |
Related Documents
:
|
11805178 - Hemodynamic effects of peritoneal dialysis solutions on the rat peritoneal membrane: ro... 15770928 - Ultrafiltration and small solute transport at initiation of pd: questioning the paradig... 3907018 - The manipulation of potassium efflux during fluoride intoxication: implications for the... 11229608 - Biological significance of reducing glucose degradation products in peritoneal dialysis... 7990698 - Increased susceptibility to lipid oxidation of low-density lipoproteins and erythrocyte... 266198 - Magnesium and calcium effects on uptake of hexoses and uridine by chick embryo fibrobla... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Pediatric obesity Volume: 7 ISSN: 2047-6310 ISO Abbreviation: Pediatr Obes Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101572033 Medline TA: Pediatr Obes Country: - |
Other Details:
|
Languages: ENG Pagination: 44-52 Citation Subset: - |
Affiliation:
|
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
F32 DK082028-01//NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A general approach to the enantioselective ?-oxidation of aldehydes via synergistic catalysis.
Next Document: The value of multislice spiral CT features of cavitary walls in differentiating between peripheral l...