Document Detail


Overweight patients with severe sleep apnea experience deeper oxygen desaturation at apneic events.
MedLine Citation:
PMID:  19845149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated differences in the depth of hypoxia produced by apneic events of the same duration (30 seconds) amongst patients with different degrees of OSAS according to their AIs (apnea indices). The relationship between apnea duration (seconds) and fall in oxygen saturation (%) was evaluated by means of a linear regression analysis. The fall induced by a 30-second apnea event was designated as the "oxygen desaturation value 30" (ODV30). We analyzed the polysomnographic recordings of 122 OSAS patients who showed significant correlations (p<0.01) between apnea duration and subsequent fall in oxygen saturation and calculated their respective ODV30. We evaluated the influence of AI and BMI on ODV30 by multi-comparison and found out that standardized partial regression coefficients of BMI and AI were 0.578 and 0.148, respectively (multi-regression analysis, SPSS). BMI was proved to be more influential on ODV30 than AI was. On the other hand, the ODV30 of mild, moderate and severe OSAS patients was 8.84 +/- 2.62% (Mean +/- S.D.), 8.25 +/- 2.45% and 10.59 +/- 3.32%, respectively. Our study shows that fall in oxygen saturation is particularly extensive in severe OSAS patients and that fall in oxygen saturation is deepened as obesity increases. We think ODV30 is a useful variable for evaluating OSAS.
Authors:
Mitsuo Sato; Masaaki Suzuki; Jun-ichi Suzuki; Yuri Endo; Yoshiaki Chiba; Masato Matsuura; Kenzo Nakagawa; Shiro Mataki; Norimasa Kurosaki; Makoto Hasegawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical and dental sciences     Volume:  55     ISSN:  1342-8810     ISO Abbreviation:  J. Med. Dent. Sci.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2009-10-22     Completed Date:  2009-11-02     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  9717112     Medline TA:  J Med Dent Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  D; IM    
Affiliation:
Department of Sleep-Related Respiratory Disorders, Tokyo Medical and Dental University Graduate School, Japan. mitsuo.gend@tmd.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anoxia / etiology*
Body Mass Index
Cardiomyopathies / etiology
Female
Humans
Linear Models
Male
Middle Aged
Overweight / complications,  physiopathology*
Oxygen / blood
Polysomnography
Sleep Apnea, Obstructive / classification,  complications,  physiopathology*
Young Adult
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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